 |
| Literature 2001 |
| 1. |
Andersen OA, Flatmark T, Hough E. High Resolution Crystal Structures of the Catalytic Domain of Human Phenylalanine Hydroxylase in its Catalytically Active Fe(II) Form and Binary Complex with Tetrahydrobiopterin. J Mol Biol 314(2):266-278.2001
|
|
| 2. |
Aoyagi M, Arvai AS, Ghosh S, Stuehr DJ, Tainer JA, Getzoff ED. Structures of tetrahydrobiopterin binding-site mutants of inducible nitric oxide synthase oxygenase dimer and implicated roles of Trp457. Biochemistry 2001;40(43):12826-12832.
|
|
| 3. |
Bader G, Schiffmann S, Herrmann A, Fischer M, Gutlich M, Auerbach G, Ploom T, Bacher A, Huber R, Lemm T. Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP. J Mol Biol 312(5):1051-1057.2001
|
|
| 4. |
Bonafe L, Blau N, Burlina AP, Romstad A, Guttler F, Burlina AB. Treatable neurotransmitter deficiency in mild phenylketonuria. Neurology 2001;57:908-910.
|
|
| 5. |
Bonafé L, Thöny B, Leimbacher W, Kierat L, Blau N. Diagnosis of Dopa-responsive dystonia and other tetrahydrobiopterin disorders by the study of biopterin metabolism in fibroblasts. Clin Chem 2001;47:477-485.
|
|
| 6. |
Bonafé L, Thöny B, Penzien JM, Czarnecki B, Blau N. Mutations in the sepiapterin reductase gene cause a novel tetrahydrobiopterin-dependent monoamine neurotransmitter deficiency without hyperphenylalaninemia. Am J Hum Genet 2001;69:269-277
|
|
| 7. |
Bracher A, Schramek N, Bacher A. Biosynthesis of pteridines. Stopped-flow kinetic analysis of GTP cyclohydrolase I. Biochemistry 2001;40(26):7896-902.
|
|
| 8. |
Chien YH, Chiang SC, Huang A, Lin JM, Chiu YN, Chou SY, Chu SY, Wang TR, Hwu WL. Treatment and outcome of Taiwanese patients with 6-pyruvoyltetrahydropterin synthase gene mutations. J Inerit Metab Dis 2001;24:815-823.
|
|
| 9. |
Chiho Sumi-Ichinose, Fumi Urano, Risa Kuroda, Tamae Ohye, Masayo Kojima, Masahiro Tazawa, Hiroaki Shiraishi, Yasumichi Hagino, Toshiharu Nagatsu, Takahide Nomura, and Hiroshi Ichinose Catecholamines and serotonin are differently regulated by tetrahydrobiopterin: a study from 6-pyruvoyltetrahydropterin synthase knockout mice JBC published August 21, 2001 as 10.1074/jbc.M102237200
|
|
| 10. |
Choi YK, Hwang YK, Park YS. Molecular cloning and disruption of a novel gene encoding UDP-glucose:tetrahydrobiopterin alpha-glucosyltransferese in the cyanobacterium Synechococcus sp PCC 7942. FEBS Letters 2001;502(3):73-78.
|
|
| 11. |
Cosentino F, Barker JE, Brand MP, Heales SJ, Werner ER, Tippins JR, West N, Channon KM, Volpe M, Luscher TF. Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol 2001;21(4):496-502.
|
|
| 12. |
Cunningham ML, Titus RG, Turco SJ, Beverley SM. Regulation of differentiation to the infective stage of the protozoan parasite Leishmania major by tetrahydrobiopterin. Science 2001;292(5515):285-7.
|
|
| 13. |
Dudesek A, Röschinger W, Muntau AC, Seidel J, Leupold D, Thöny B, Blau N. Molecular analysis and long term follow-up of patients with different forms of 6-pyruvoyl-tetrahydropterin synthase deficiency. Eur J Pediatr 2001:267-276.
|
|
| 14. |
Erlandsen H, Stevens RC. A structural hypothesis for BH4 responsiveness in patiens with mild forms of hyperphenylalaninemia and phenylketonuria. J Inherit Metab Dis 2001;24:213-230.
|
|
| 15. |
Fujimoto Y, Sakuma S, Iba Y, Sasaki T, Fujita T. Tetrahydrobiopterin attenuates modulation of platelet 12-lipoxygenase and cyclooxygenase activities by nitric oxide. Nitric Oxide 2001;5(1):77-81.
|
|
| 16. |
Galley HF, Le Cras AE, Yassen K, Grant IS, Webster NR. Circulating tetrahydrobiopterin in patients with septic shock. Br J Anaest 2001;86:578-580.
|
|
| 17. |
Gieseg SP, Maghzal G, Glubb D. Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin. Free Radic Res 2001;34(2):123-36.
|
|
| 18. |
Golderer G, Werner ER, Heufler C, Strohmaier W, Grobner P, Werner-Felmayer G. GTP cyclohydrolase I mRNA: novel splice variants in the slime mould Physarum polycephalum and in human monocytes (THP-1) indicate conservation of mRNA processing. Biochem J 2001;355(Pt 2):499-507.
|
|
| 19. |
Golderer G, Werner ER, Leitner S, Grobner P, Werner-Felmayer G. Nitric oxide synthase is induced in sporulation of Physarum polycephalum. Genes Dev. 2001 May 15;15(10):1299-309.
|
|
| 20. |
Gorren AC, Kungl AJ, Schmidt K, Werner ER, Mayer B. Electrochemistry of pterin cofactors and inhibitors of nitric oxide synthase. Nitric Oxide 2001;5(2):176-86.
|
|
| 21. |
Gourley DG, Schuttelkopf AW, Leonard GA, Luba J, Hardy LW, Beverley SM, Hunter WN. Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites. Nat Struct Biol 2001;8(6):521-5. (2MB)
|
|
| 22. |
Gruhn N, Aldershvile J, Boesgaard S. Tetrahydrobiopterin improves endothelium-dependent vasodilation in nitroglycerin-tolerant rats. Eur J Paharmacol 2001;416:245-249.
|
|
| 23. |
Hahn H, Trant MR, Brownstein MJ, Harper RA, Milstien S, Butler IJ. Neurologic and psychiatric manifestations in a family with a mutation in exon 2 of the guanosine triphosphate-cyclohydrolase gene. Arch Neurol 2001;58(5):749-55.
|
|
| 24. |
Hillinger S, Sandera P, Carboni GL, Stammberger U, Zalunardo M, Schoedon G, Schmid RA. Survival and graft function in a large animal lung transplant model after 30 h preservation and substitution of the nitric oxide pathway. Eur J Cardiothorac Surg 2001;20(3):508-13.
|
|
| 25. |
Hirayama K, Shimoji M, Swick L, Meyer A, Kapatos G. Characterization of GTP cyclohydrolase I gene expression in the human neuroblastoma SKN-BE(2)M17: enhanced transcription in response to cAMP is conferred by the proximal promoter. J Neurochem 2001;79(3):576-587.
|
|
| 26. |
Hoekstra R, van den Broek WW, Fekkes D, Bruijn JA, Mulder PG, Pepplinkhuizen L. Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression. Psychiatry Res 2001;103(2-3):115-23.
|
|
| 27. |
Hoenicka J, Vidal L, Godoy M, Ochoa JJ, Garcia De Yebenes J. New nonsense mutation in the GTP-cyclohydrolase I gene in L-DOPA responsive dystonia-parkinsonism. Mov Disord 2001;16(2):364-6.
|
|
| 28. |
Hong HJ, Hsiao G, Cheng TH, Yen MH. Supplemention with tetrahydrobiopterin suppresses the development of hypertension in spontaneously hypertensive rats. Hypertension 38(5):1044-1048.2001
|
|
| 29. |
Hong KM, Kim YS, Paik MK. A novel nonsense mutation of the GTP cyclohydrolase i gene in a family with Dopa-responsive dystonia. Hum Hered 2001;52(1):59-60.
|
|
| 30. |
Johns DG, Dorrance AM, Tramontini NL, Webb RC. Glucocorticoids inhibit tetrahydrobiopterin-dependent endothelial function. Exp Biol Med (Maywood) 2001;226(1):27-31.
|
|
| 31. |
Johnson JL, Coyne KE, Rajagopalan KV, Van Hove JLK, Mackay M, Pitt J, Boneh A. Molybdopterin synthase mutations in a mild case of molybdenum cofactor deficiency. Ame J Med Genet 2001;104:169-173.
|
|
| 32. |
Kalkanoglu HS, Romstad A, Coskun T, Guttler F. Evaluation of a fetus at risk for dihydropteridine reductase deficiency by direct mutation analysis using denaturing gradient gel electrophoresis. Prenat Diagn 2001;21:868-870.
|
|
| 33. |
Kanaya S, Ikeda H, Haramaki N, Murohara T, Imaizumi T. Intraplatelet tetrahydrobiopterin plays an important role in regulating canine coronary arterial thrombosis by modulating intraplatelet nitric oxide and superoxide generation. Circulation 2001;104: 2478-2484.
|
|
| 34. |
Katusic ZS. Vascular endothelial dysfunction: does tetrahydrobiopterin play a role? Am J Physiol Heart Circ Physiol 2001;281(3):H981-6.
|
|
| 35. |
Kim H, You S, Foster LK, Farris J, Choi YJ, Foster DN. Differential expression of chicken dimerization cofactor of hepatocyte nuclear factor-1 (DcoH) and its novel counterpart, DcoHalpha. Biochem J 2001;354(Pt 3):645-53.
|
|
| 36. |
Kohnen SL, Mouithys-Mickalad AA, Deby-Dupont GP, Deby CM, Lamy ML, Noels AF. Oxidation of tetrahydrobiopterin by peroxynitrite or oxoferryl species occurs by a radical pathway. Free Radic Res 2001;35(6):709-21.
|
|
| 37. |
Kunz DA, Fernandez RF, Parab P. Evidence that bacterial cyanide oxygenase is a pterin-dependent hydroxylase. Biochem Biophys Res Commun 2001;287(2):514-8.
|
|
| 38. |
Laursen JB, Somers M, Kurz S, McCann L, Warnholtz A, Freeman BA, Tarpey M, Fukai T, Harrison DG. Endothelial regulation of vasomotion in apoE-deficient mice: implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation 2001;103(9):1282-8.
|
|
| 39. |
Lindner M, Haas D, Zschocke J, Burgard P. Tetrahydrobiopterin responsiveness in phenylketonuria differs between patients with the same genotype. Mol Genet Metab 2001;73(1):104-6.
|
|
| 40. |
Liu TT, Chang YH, Chiang SH, Yang YL, Yu WM, Hsiao KJ. Identification of three new 6-pyruvoyl-tetrahydropterin synthase gene mutations (226C>T, IVS3+1G>A, 116-119delTGTT) in Chinese hyperphenylalaninemia caused by tetrahydrobiopterin synthasis deficiency. Human Mutat 2001;18:83.
|
|
| 41. |
Liu TT, Chiang SH, Wu SJ, Hsiao KJ. Tetrahydrobiopterin-deficient hyperphenylalaninemia in the Chinese. Clin Chim Acta 2001;313(1-2):157-69.
|
|
| 42. |
Maita N, Okada K, Hirotsu S, Hatakeyama K, Hakoshima T. Preparation and crystallization of the stimulatory and inhibitory complexes of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Acta Crystallogr D Biol Crystallogr 2001;57(Pt 8):1153-6.
|
|
| 43. |
Malakaneh M, Rasaee MJ, Rahbarizadeh F, Madani R, Forozandeh MM, Khabiri K, Alimohammadian MH. Characterization of a monoclonal antibody against neopterin using an enzyme-linked immunosorbent assay with penicillinase as label. Hybridoma 2001;20(2):117-21.
|
|
| 44. |
Marinos RS, Zhang W, Wu G, Kelly KA, Meininger CJ. Tetrahydrobiopterin levels regulate endothelial cell proliferation. Am J Physiol Heart Circ Physiol 2001;281(2):H482-9.
|
|
| 45. |
Nakamura K, Bindokas VP, Kowlessur D, Elas M, Milstien S, Marks JD, Halpern HJ, Kang UJ. Tetrahydrobiopterin scavenges superoxide in dopaminergic neurons. J Biol Chem 2001;276(37):34402-7.
|
|
| 46. |
Noguchi T, Sagami I, Daff S, Shimizu T. Important role of tetrahydrobiopterin in no complex formation and interdomain electron transfer in neuronal nitric-oxide synthase. Biochem Biophys Res Commun 2001;282(5):1092-7.
|
|
| 47. |
Pantke MM, Reif A, Valtschanoff JG, Shutenko Z, Frey A, Weinberg RJ, Pfleiderer W, Schmidt HH. Pterin interactions with distinct reductase activities of NO synthase. Biochem J 2001;356(Pt 1):43-51.
|
|
| 48. |
Park H, Seong C, Jang J, Yoon J, Han K, Cho NY, Baek K. Promoter analysis of the Drosophila melanogaster gene encoding the pterin 4 alpha-carbinolamine dehydratase. Molecules & Cells 2001;12:233-238.
|
|
| 49. |
Pelletier I, Bally-Cuif L, Ziegler I. Cloning and developmental expression of zebrafish GTP cyclohydrolase I. Mechan Develop 2001; 109:99-103.
|
|
| 50. |
Roy G, Kundig C, Olivier M, Papadopoulou B, Ouellette M. Adaptation of Leishmania cells to in vitro culture results in a more efficient reduction and transport of biopterin. Exp Parasitol 2001;97(3):161-8.
|
|
| 51. |
Sakai T. Effects of tetrahydrobiopterin on ataxia in Machado-Joseph disease may be based upon the theory of 'cerebellar long-term depression'. Med Hypotheses 2001;57(2):180-2.
|
|
| 52. |
Sakuma S, Fujimoto Y, Gohda Y, Fujita T. Tetrahydrobiopterin inhibits copper-induced oxidation of low density lipoprotein. Res Commun Mol Pathol Pharmacol 2000;107(5-6):397-406.
|
|
| 53. |
Schallreuter KU, Moore J, Wood JM, Beazley WD, Peters EM, Marles LK, Behrens-Williams SC, Dummer R, Blau N, Thony B. Epidermal H2O2 accumulation alters tetrahydrobiopterin (6BH4) recycling in vitiligo: Identification of a general mechanism in regulation of all 6BH4-dependent processes? J Invest Dermatol 2001;116(1):167-174.
|
|
| 54. |
Schramek N, Bracher A, Bacher A. Biosynthesis of riboflavin - Single turnover kinetic analysis of GTP cyclohydrolase II. J Biol Chem 2001;276: 44157-44162.
|
|
| 55. |
Schwartz IF, Schwartz D, Wollman Y, Chernichowski T, Blum M, Levo Y, Iaina A. Tetrahydrobiopterin augments arginine transport in rat cardiac myocytes through modulation of CAT-2 mRNA. J Lab Clin Med 2001;137(5):356-62.
|
|
| 56. |
Setoguchi S, Mohri M, Shimokawa H, Takeshita A. Tetrahydrobiopterin improves endothelial dysfunction in coronary microcirculation in patients without epicardial coronary artery disease. J Am Coll Cardiol 2001;38(2):493-8.
|
|
| 57. |
Shimizu S, Ishii M, Iwasaki M, Shiota K, Yamamoto T, Kiuchi Y. Carboxy-PTIO increases the tetrahydrobiopterin level in mouse brain microvascular endothelial cells. Japanese J. Paharcol 2001;87:51-60.
|
|
| 58. |
Shinozaki K, Hirayama A, Nishio Y, Yoshida Y, Ohtani T, Okamura T, Masada M, Kikkawa R, Kodama K, Kashiwagi A. Coronary endothelial dysfunction in the insulin-resistant state is linked to abnormal pteridine metabolism and vascular oxidative stress. J Am Coll Cardiol 38(7):1821-1828.2001
|
|
| 59. |
Skrygan M, Bartholomé B, Bonafé L, Blau N, Bartholomé K. A splice mutation in the GTP cyclohydrolase I gene causes Dopa-responsive dystonia by exon skipping. J Inherit Metab Dis 2001;24:i345-351.
|
|
| 60. |
Spaapen LJM, Bakker JA, Velter C, Loots W, Rubio ME, Forget PP, Duran M, Dorland L, de Konig TJ, Poll-The BT, Ploos van Amstel HK, Bekhof J, Blau N. Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency in Dutch neonates. J Iner Metabol Dis 2001;24:325-358.
|
|
| 61. |
Sugimoto T, Ikemoto K, Murata S, Tazawa M, Nomura T, Hagino Y, Ichinose H, Nagatsu T, Wada A. A convenient determination of chiral pteridines: Application of fluorescence detected circular dichroism (FDCD) of the major pterin from E. coli. Heterocycles .2001;54:283-290
|
|
| 62. |
Sugimoto T, Ikemoto K, Murata S, Tazawa M, Nomura T, Hagino Y, Ichinose H, Nagatsu T. Identification of (6R)-5,6,7,8-tetrahydro-D-monapterin as the native pteridine in Tetrahymena pyriformis. Helv Chim Acta 2001; 84:918-927.
|
|
| 63. |
Sun H, Patel KP, Mayhan WG. Tetrahydrobiopterin, a cofactor for NOS, improves endothelial dysfunction during chronic alcohol consumption. Am J Physiol Heart Circ Physiol 281(5):H1863-1869.2001
|
|
| 64. |
Tanaka J, Koshimura K, Sohmiya M, Murakami Y, Kato Y. Involvement of tetrahydrobiopterin in trophic effect of erythropoietin on PC12 cells. Biochem Biophys Res Commun 2001;289(2):358-362.
|
|
| 65. |
Tiefenbacher CP. Tetrahydrobiopterin: a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction? Am J Physiol Heart Circ Physiol 2001;280(6):H2484-8.
|
|
| 66. |
Trefz FK, Aulea-Scholz C, Blau N. Successful treatment of phenylketonuria by tetrahydrobiopterin. Eur J Pediatr 2001:315.
|
|
| 67. |
v Strandmann EP, Senkel S, Ryffel G, Hengge UR. Dimerization co-factor of hepatocyte nuclear factor 1/pterin-4alpha- carbinolamine dehydratase is necessary for pigmentation in xenopus and overexpressed in primary human melanoma lesions. Am J Pathol 2001;158(6):2021-9.
|
|
| 68. |
van Hinsbergh VW. NO or H2O2 for Endothelium-dependent vasorelaxation : Tetrahydrobiopterin makes the difference. Arterioscler Thromb Vasc Biol 2001;21(5):719-21.
|
|
| 69. |
Van Wagoner RM, Jompa J, Tahir A, Ireland CM. A novel modified pterin from a Eudistoma species ascidian. J Nat Prod 2001;64(8):1100-1.
|
|
| 70. |
Vasquez-Vivar J, Whitsett J, Martasek P, Hogg N, Kalyanaraman B. Reaction of tetrahydrobiopterin with superoxide: EPR-kinetic analysis and characterization of the pteridine radical. Free Radic Biol Med 31(8):975-985.2001
|
|
| 71. |
Verma S, Dumont AS, Maitland A. Tetrahydrobiopterin attenuates cholesterol induced coronary hyperreactivity to endothelin. Heart 86(6):706-708.2001
|
|
| 72. |
Walter R, Kaufmann PA, Buck A, Berthold T, Wyss C, von Schulthess GK, Schaffner A, Schoedon G. Tetrahydrobiopterin increases myocardial blood flow in healthy volunteers: a double-blind, placebo-controlled study. Swiss Med Wkly 2001;131(7-8):91-4.
|
|
| 73. |
Walter R, Schaffner A, Schoedon G. Tetrahydrobiopterin in the vascular system. Pteridines 2001;12:93-120.
|
|
| 74. |
Wang ZQ, Wei CC, Ghosh S, Meade AL, Hemann C, Hille R, Stuehr DJ. A conserved tryptophan in nitric oxide synthase regulates heme-dioxy reduction by tetrahydrobiopterin. Biochemistry 2001;40(43):12819-12825.
|
|
| 75. |
Waters PJ, Scriver CR, Parniak MA. Homomeric and heteromeric interactions between wild-type and mutant Phenylalanine hydroxylase subunits: Evaluation of two-hybrid approaches for functional analysis of mutations causing hyperphenylalaninemia. Mol Genet Metab 2001;73(3):230-8.
|
|
| 76. |
Wirleitner B, Czaputa R, Oettl K, Bock G, Widner B, Reibnegger G, Baier G, Fuchs D, Baier-Bitterlich G. Induction of apoptosis by 7,8-dihydroneopterin: involvement of radical formation. Immunobiology 2001;203(4):629-41.
|
|
| 77. |
Yoneyama T, Hatakeyama K. Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes. Protein Sci 2001;10(4):871-878.
|
|
| 78. |
Yoneyama T, Wilson LM, Hatakeyama K. GTP cyclohydrolase I feedback regulatory protein-dependent and indepandent inhibitors of GTP cyclohydrolase I. Arch Biochem Biophys 2001;388:67-73.
|
|
| 79. |
Yoshida S, Lee YH, Hassan M, Shoji T, Onuma K, Hasegawa H, Nakagawa H, Serizawa S, Amayasu H. Parallel induction of nitric oxide and tetrahydrobiopterin synthesis in alveolar macrophages. Respiration 2001;68(3):299-306.
|
|
| 80. |
Yu PK, Yu DY, Cringle SJ, Su EN. Tetrahydrobiopterin reverses the impairment of acetylcholine-induced vasodilatation in diabetic ocular microvasculature. J Ocul Pharmacol Ther 2001;17(2):123-9.
|
|
|
