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Literature : 2002
Literature 2002
1. Abeling NGGM, Duran M, Bakker HD, van Gennip AH, van Cruchten AG, Stroomer AEM, Blau N, OPoll-The BT. Sepiapterin reductase deficiency in a patient with mild methylamalonic aciduria and spastic paresis. J Inherit Metab Dis 2002;25(Suppl. I):22. Abstract
 
2. Atmaca M. Kuloglu M. Tezcan E. Onal S. Ustundag B. Neopterin levels and dexamethasone suppression test in posttraumatic stress disorder. European Archives of Psychiatry & Clinical Neuroscience. 252(4):161-165, 2002
 
3. Azzouz M. Martin-Rendon E. Barber RD. Mitrophanous KA. Carter EE. Rohll JB. Kingsman SM. Kingsman AJ. Mazarakis ND. Multicistronic lentiviral vector-mediated striatal gene transfer of aromatic L-amino acid decarboxylase, tyrosine hydroxylase, and GTP cyclohydrolase I induces sustained transgene expression, dopamine production, and functional improvement in a rat model of Parkinson's disease. Journal of Neuroscience. 22(23):10302-10312, 2002
 
4. Bardelli, T., M. A. Donati, S. Gasperini, F. Ciani, F. Balli, N. Blau, A. Morrone and E. Zammarchi (2002). Two novel genetic lesions and a common BH4-responsive mutation of the PAH gene in Italian patients with hyperphenylalaninemia. Mol Genet Metab 77: 260-266.
 
5. Basset G. Quinlivan EP. Ziemak MJ. de la Garza RD. Fischer M. Schiffmann S. Bacher A. Gregory JF. Hanson AD. Folate synthesis in plants: The first step of the pterin branch is mediated by a unique bimodular GTP cyclohydrolase I. Proceedings of the National Academy of Sciences of the United States of America. 99(19):12489-12494, 2002
 
6. Bauer M. Suppmann S. Meyer M. Hesslinger C. Gasser T. Widmer HR. Ueffing M. Glial cell line-derived neurotrophic factor up-regulates GTP-cyclohydrolase I activity and tetrahydrobiopterin levels in primary dopaminergic neurones. Journal of Neurochemistry. 82(5):1300-1310, 2002 Sep.
 
7. Bayle JH, Randazzo F, Johnen G, Kaufman S, Nagy A, Rossant J, Crabtree GR (2002) Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene. J Biol Chem M201983200: in press (online MS)
 
8. Bayle, J. H., F. Randazzo, G. Johnen, S. Kaufman, A. Nagy, J. Rossant and G. R. Crabtree (2002). Hyperphenylalaninemia and impaired glucose tolerance in mice lacking the bifunctional DCoH gene. J Biol Chem 277(32): 28884-91.
 
9. Bernegger, C. and N. Blau High frequency of tetrahydrobiopterin-responsiveness among hyperphenylalaninemias: A study of 1919 patients observed from 1988 to 2002. Mol Genet Metab 77: 304-313, 2002
 
10. Blau N, Bernegger C. Importance of tetrahydrobiopterin (BH4) loading test in the diagnosis of BH4-responsive HPA/PKU. J Inherit Metab Dis 2002;25(Suppl. I):20.
 
11. Blau N, Trefz FK. Tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency: Possible regulation of gene expression in a patient with the homozygous L48S mutation. Mol Genet Metabol 2002;75:186-187.
 
12. Blau, N., C. Bernegger and F. K. Trefz (2002). Tetrahydrobiopterinresponsive hyperphenylalaninemia due to homozygous mutations in the phenylalanine hydroxylase gene. Eur J Pediatr: DOI 10.107/s004131-1034-5 online.
 
13. Cai S. Alp NJ. McDonald D. Smith I. Kay J. Canevari L. Heales S. Channon KM. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: effects on nitric oxide synthase activity, protein levels and dimerisation. Cardiovascular Res. 55(4):838-849, 2002
 
14. Cheng, C. R., C. J. Huang, Y. T. Lu, Y. W. Hsu, P. Tsai, N. Y. Su and J. W. Skimming (2002). "GTPCH is not a rate-limiting factor for hemorrhagic shock-induced hepatic nitric oxide biosynthesis." Acta Anaesthesiol Sin 40(3): 109-16.
 
15. Chien YH, Peng SF, Wang TR, Hwu WL. Cranial MR spectroscopy of tetrahydrobiopterin deficiency. AJNR Am J Neuroradiol 2002;23(6):1055-8.
 
16. Czapski GA, Sun GY, Strosznajder JB. Inhibition of N-methyl-D-aspartic acid-nitric oxide synthase in rat hippocampal slices by ethanol. Evidence for the involvement of tetrahydrobiopterin but not lipid peroxidation. J Biomed Sci 2002;9(1):3-9.
 
17. Delgado-Esteban M. Almeida A. Medina JM. Tetrahydrobiopterin deficiency increases neuronal vulnerability to hypoxia. Journal of Neurochemistry. 82(5):1148-1159, 2002 Sep.
 
18. Divergent GTP cyclohydrolase-1 expression and tetrahydrobiopterin levels in LPS-treated endothelial cells and cardiac myocytes Vivar JV, Whitsett J, Konorev E, Kalyanaraman B, Kalivendi S FREE RADICAL BIOLOGY AND MEDICINE 33: 170 Suppl. 2 2002
 
19. Dole VS, Myler PJ, Stuart KD, Madhubala R. Expression of biopterin transporter (BT1) protein in Leishmania. FEMS Microbiol Lett 2002;208(1):89-91.
 
20. Duggan S. Rait C. Platt A. Gieseg SP. Protein and thiol oxidation in cells exposed to peroxyl radicals is inhibited by the macrophage synthesised pterin 7,8-dihydroneopterin. Biochimica et Biophysica Acta - Molecular Cell Research. 1591(1-3):139-145, 2002
 
21. Elzaouk L, Osmani H, Romstad A, Friedman J, Maccollin M, Thöny B, Blau N. Sepiapterin reductase deficiency: Molecular analysis in a new case presenting with neurotransmitter deficiency without hyperphenylalaninemia. In: Milstien S, Kapatos G, Levine RA, Shane B, eds. Chemistry and Biology of Pteridines and Folates. Norwell: Kluwer Academic Publishers, 2002: 277-284.
 
22. Enzinger C, Wirleitner B, Lutz C, Bock G, Tomaselli B, Baier G, Fuchs D, Baier-Bitterlich G. 7,8-Dihydroneopterin induces apoptosis of Jurkat T-lymphocytes via a Bcl-2-sensitive pathway. Eur J Cell Biol 2002;81(4):197-202.
 
23. Enzinger C, Wirleitner B, Spottl N, Bock G, Fuchs D, Baier-Bitterlich G. Reduced pteridine derivatives induce apoptosis in PC12 cells. Neurochem Int 2002;41(1):71-8.
 
24. Erlandsen, H., J. Y. Kim, M. G. Patch, A. Han, A. Volner, M. M. Abu-Omar and R. C. Stevens (2002). Structural comparison of bacterial and human iron-dependent phenylalanine hydroxylases: similar fold, different stability and reaction rates. J Mol Biol 320(3): 645-61.
 
25. Fitzal F. Redl H. Strohmaier W. Werner ER. Bahrami S. A 4-amino analogue of tetrahydrobiopterin attenuates endotoxin-induced hemodynamic alterations and organ injury in rats. Shock. 18(2):158-162, 2002
 
26. Foster JA. Christopherson PL. Levine RA. GTP cyclohydrolase I induction in striatal astrocytes following intrastriatal kainic acid lesion. Journal of Chemical Neuroanatomy. 24(3):173-179, 2002
 
27. Fujimoto K, Takahashi SY, Katoh S. Mutational analysis of sites in sepiapterin reductase phosphorylated by Ca(2+)/calmodulin-dependent protein kinase II. Biochim Biophys Acta 2002;1594(1):191-8.
 
28. Fukuda Y, Teragawa H, Matsuda K, Yamagata T, Matsuura H, Chayama K. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002;87(3):264-9.
 
29. Furukawa Y, Kapataos G, Hyaycock JW, Worsley J, Wong H, Kish SJ, Nygaard TG (2002) Brain biopterin and tyrosine hydroxylase in asymtomatic dopa-responsive dystonia. Ann Neurol 51: 637-641
 
30. Goswami S. Adak AK. The first microwave-assisted regiospecific synthesis of 6-substituted pterins. Tetrahedron Letters. 43(46):8371-8373, 2002
 
31. Gramsbergen, J.B., et al., Glutathione depletion in nigrostriatal slice cultures: GABA loss, dopamine resistance and protection by the tetrahydrobiopterin precursor sepiapterin. Brain Res, 2002. 935(1-2): p. 47-58.
 
32. Grimes, D.A., et al., Phenocopies in a large GCH1 mutation positive family with dopa responsive dystonia: confusing the picture? J Neurol Neurosurg Psychiatry, 2002. 72(6): p. 801-4.
 
33. Gruber G, Lirk P, Amann A, et al. Neopterin as a marker of immunostimulation: an investigation in anaesthetic workplaces. Anaesthesia 2002;57(8):747-50.
 
34. Habecker, B. A., M. G. Klein, N. C. Sundgren, W. Li and W. R. Woodward (2002). "Developmental regulation of neurotransmitter phenotype through tetrahydrobiopterin." J Neurosci 22(21): 9445-52.
 
35. Hennermann JB, Vetter B, Kulozik AE, Mönch E. Partial and total tetrahydrobiopterin-responsiveness in classical and mild phenylketonuria (PKU). J Inherit Metab Dis 2002;25(Suppl. I):21.
 
36. Hoekstra, R. and D. Fekkes (2002). "Pteridines and affective disorders." Acta Neuropsychiatr 14: 120-126.
 
37. Hoffmann G, Gollnick F, R. M. Neopterin inhibits ATP-induced calcium release in alveolar epithelial cells in vitro. Mediators Inflammat 2002;11:181-185.
 
38. Holdengreber V, Krieger C, Gutlich M, Schramek N, Vechoropoulos M, Fischer M, Bacher A, Ben-Shaul Y. Localization of two enzymes of the tetrahydrobiopterin biosynthetic pathway in embryonic chick retina. J Histochem Cytochem 2002;50(2):265-74.
 
39. Horejsi R, Jung C, Moller R, Tafeit E, Reibnegger G. Generation of carbon monoxide and iron from hemeproteins in the presence of 7,8-dihydroneopterin. Biochim Biophys Acta 2002;1571(2):124-30.
 
40. Horejsi R, Moller R, Tafeit E, et al., Neopterin, dihydroneopterin, tetrahydroneopterin: Different structures-increasing capacity cleaving the porphyrin in heme proteins, PTERIDINES 13 (4): 115-120 DEC 2002
 
41. Huisman A, Vos I, van Faassen EE, Joles JA, Grone HJ, Martasek P, van Zonneveld AJ, Vanin AF, Rabelink TJ. Anti-inflammatory effects of tetrahydrobiopterin on early rejection in renal allografts: modulation of inducible nitric oxide synthase. Faseb J 2002;16(9):1135-7.
 
42. Hurshman AR, Marletta MA. Reactions catalyzed by the heme domain of inducible nitric oxide synthase:[?] evidence for the involvement of tetrahydrobiopterin in electron transfer. Biochemistry 2002;41(10):3439-56.
 
43. Hwang YK, Kang JY, Woo HJ, Choi YK, Park YS (2002) Functional investigation of a gene encoding pteridine glycosyltransferase for cyanopterin synthesis in Synechocystis sp. PCC 6803. Biochim Biophys Acta 1570: 141-4
 
44. Hyndman ME, Verma S, Rosenfeld RJ, Anderson TJ, Parsons HG (2002) Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function. Am J Physiol Heart Circ Physiol 282: H2167-72
 
45. Ihara M. Kohara N. Urano F. Ichinose H. Takao S. Nishida T. Saiki H. Kawamoto Y. Ikeda A. Takagi S. Shibasaki H. Neuroleptic malignant syndrome with prolonged catatonia in a dopa-responsive dystonia patient. Neurology. 59(7):1102-1104, 2002
 
46. Ikemoto K, Sugimoto T, Murata S, Tazawa M, Nomura T, Ichinose H, Nagatsu T. (6R)-5,6,7,8-tetrahydro-L-monapterin from Escherichia coli, a novel natural unconjugated tetrahydropterin. Biol Chem 2002;383(2):325-30.
 
47. Ikemoto, K., T. Suzuki, H. Ichinose, T. Ohye, A. Nishimura, K. Nishi, I. Nagatsu and T. Nagatsu (2002). "Localization of sepiapterin reductase in the human brain." Brain Res 954(2): 237-46.
 
48. Ikeno M. Inagaki H. Nagata K. Morita M. Ichinose H. Okazaki T. Generation of human artificial chromosomes expressing naturally controlled guanosine triphosphate cyclohydrolase I gene. Genes to Cells. 7(10):1021-1032, 2002
 
49. Illarionova, V., W. Eisenreich, M. Fischer, C. Haussmann, W. Romisch, G. Richter and A. Bacher (2002). Biosynthesis of Tetrahydrofolate. Stereochemistry of dihydroneopterin aldolase. J Biol Chem 277(32): 28841-7.
 
50. Inaba A, Yokose S, Fujimoto K, Katayama T, S. K. Gene expression of enzymes generating tetrahydrobiopterin, an essential cofactor for NO synthase, in bone and cultured bone cells. Acta Histichim Cytochim 2002;35:175-183.
 
51. Ishii M, Shimizu S, Shiota K, Yamamoto S, Kiuchi Y, Yamamoto T. Stimulation of tetrahydrobiopterin synthesis by cyclosporin A in mouse brain microvascular endothelial cells. Int J Biochem Cell Biol 2002;34(9):1134-41.
 
52. Kaiser J. Schramek N. Eberhardt S. Puttmer S. Schuster M. Bacher A. Biosynthesis of vitamin B-2 - An essential zinc ion at the catalytic site of GTP cyclohydrolase II. European Journal of Biochemistry. 269(21):5264-5270, 2002
 
53. Klein C. Hedrich K. Kabakci K. Mohrmann K. Wiegers K. Landt O. Hagenah J. Schwinger E. Pramstaller PP. Ozelius LJ. Gucuyener K. Aysun S. Demir E. Exon deletions in the GCHI gene in two of four Turkish families with dopa-responsive dystonia. Neurology. 59(11):1783-1786, 2002
 
54. Koch R, Güttler F, Blau N. Mental illness in mild PKU responds to biopterin. Mol Genet Metab 2002;75:284-286.
 
55. Koshimura K, Tanaka J, Murakami Y, Kato Y. Involvement of nitric oxide in glucose toxicity on differentiated PC12 cells: prevention of glucose toxicity by tetrahydrobiopterin, a cofactor for nitric oxide synthase. Neurosci Res 2002;43(1):31-8.
 
56. Kotsonis P, Frohlich LG, Raman CS, et al. Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. J Biol Chem 2001;276(52):49133-41.
 
57. Laich A, Neurauter G, Wirleitner B, Fuchs D. Degradation of serum neopterin during daylight exposure (letter). Clin Chim Acta 2002;322:175-178.
 
58. Lam KK, Ho ST, Yen MH. Tetrahydrobiopterin improves vascular endothelial function in ovariectomized rats. J Biomed Sci 2002;9(2):119-25.
 
59. Lässker U, Zschocke J, Blau N, Santer R. Tetrahydrobiopterin responsiveness in phenylketonuria. Two new cases and a review of molecular genetic findings. J Inherit Metab Dis 2002;25:65-70.
 
60. Le GS, Jesuthasan S. Analysis of xanthophore and pterinosome biogenesis in zebrafish using methylene blue and pteridine autofluorescence. Pigment Cell Res 2002;15(1):27-31.
 
61. Leuzzi V. Carducci C. Cardona F. Artiola C. Antonozzi I. Autosomal dominant GTP-CH deficiency presenting as a dopa-responsive myoclonus-dystonia syndrome. Neurology. 59(8):1241-1243, 2002
 
62. Li, H. Y., Y. M. Yao, Z. G. Shi, N. Dong, Y. Yu, L. R. Lu and Z. Y. Sheng (2002). "Effect of 2,4-diamino-6-hydroxy-pyrimidine on postburn Staphylococcus aureus sepsis in rats." Crit Care Med 30(11): 2520-7.
 
63. Lye LF. Cunningham ML. Beverley SM. Characterization of quinonoid-dihydropteridine reductase (QDPR) from the lower eukaryote Leishmania major. Journal of Biological Chemistry. 277(41):38245-38253, 2002
 
64. Maita N, Okada K, Hatakeyama K, Hakoshima T. Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP. Proc Natl Acad Sci U S A 2002;99(3):1212-7.
 
65. Matalon R, Koch R, Michals-Matalon K, Mosley K, Stevens R. Tetrahydrobiopterin-responsive phenylalanine hydroxylase mutations. J Inherit Metab Dis 2002;25(Suppl. I):23.
 
66. McKinney J, Teigen K, Froystein NA, Salaun C, Knappskog PM, Haavik J, Martinez A. Conformation of the substrate and pterin cofactor bound to human tryptophan hydroxylase. Important role of Phe313 in substrate specificity. Biochemistry 2001;40(51):15591-601.
 
67. Mueller NJ, Walter RB, Linscheid P, et al. Differential inhibition of constitutive and inducible nitric oxide synthase in vascular endothelial cells by analogues of tetrahydrobiopterin, PTERIDINES 13 (4): 126-132 DEC 2002
 
68. Müller U, Steinberger D, Topka H. Mutations of GCH1 in dopa-responsive dystonia. J Neural Transm 2002;109(S1):321-328.
 
69. Muramatsu S, Fujimoto K, Ikeguchi K, Shizuma N, Kawasaki K, Ono F, Shen Y, Wang L, Mizukami H, Kume A, Matsumura M, Nagatsu I, Urano F, Ichinose H, Nagatsu T, Terao K, Nakano I, Ozawa K. Behavioral recovery in a primate model of Parkinson's disease by triple transduction of striatal cells with adeno-associated viral vectors expressing dopamine-synthesizing enzymes. Hum Gene Ther 2002;13(3):345-54.
 
70. Neopterin and macrophage inflammatory protein-1 alpha in the cerebrospinal fluid of schizophrenic patients: No evidence of intrathecal inflammation Nikkila HV, Ahokas A, Wahlbeck K, Rimon R, Andersson LC NEUROPSYCHOBIOLOGY 46 (4): 169-172 2002
 
71. Ohtsuki M, Shiraishi H, Kato T, Tazawa M, Sumi-Ichinose C, Tada S, Udagawa Y, Itoh M, Hishida H, Ichinose H, Nagatsu T, Hagino Y, Nomura T. cAMP inhibits cytokine-induced biosynthesis of tetrahydrobiopterin in human umbicial vein endothelial cells. Life Sci 2002;70:2187-2198.
 
72. Omura I, Mizutani M, Goto S, Hashimoto R, Kitagami T, Miura H, Ohta T (2002) Plasma biopterin levels and depressive state in pregnancy and the early puerperal period. Neuropsychobiology 45: 134-8
 
73. Omura, I., M. Mizutani, S. Goto, R. Hashimoto, T. Kitagami, H. Miura and T. Ohta (2002). "Plasma biopterin levels and depressive state in pregnancy and the early puerperal period." Neuropsychobiology 45(3): 134-8.
 
74. Opposing roles of endogenous methylarginines on superoxide generation from NOS-1 under conditions of tetrahydrobiopterin depletion. Cardounel A, Zweier J FREE RADICAL BIOLOGY AND MEDICINE 33: 213 Suppl. 2 2002
 
75. Ouellette M, Drummelsmith J, El Fadili A, Kundig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. Int J Parasitol 2002;32(4):385-98.
 
76. Ouellette M, Drummelsmith J, El Fadili A, Kundig C, Richard D, Roy G. Pterin transport and metabolism in Leishmania and related trypanosomatid parasites. Int J Parasitol 2002;32(4):385-98.
 
77. Oxidation of tetrahydrobiopterin by peroxynitrite and uncoupling of endothelial NO synthase (eNOS) Dikalov S, Kuzkaya N, Weissman N, Harrison D FREE RADICAL BIOLOGY AND MEDICINE 33: 217 Suppl. 2 2002
 
78. Pannirselvam, M., et al., Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol, 2002. 136(2): p. 255-63.
 
79. Papadopoulou B, Roy G, Breton M, Kundig C, Dumas C, Fillion I, Singh AK, Olivier M, Ouellette M. Reduced infectivity of a Leishmania donovani biopterin transporter genetic mutant and its use as an attenuated strain for vaccination. Infect Immun 2002;70(1):62-8.
 
80. Park, J. H., H. J. Na, Y. G. Kwon, K. S. Ha, S. J. Lee, C. K. Kim, K. S. Lee, T. Yoneyama, K. Hatakeyama, P. K. Kim, T. R. Billiar and Y. M. Kim (2002). "Nitric Oxide (NO) Pretreatment Increases Cytokine-induced NO Production in Cultured Rat Hepatocytes by Suppressing GTP Cyclohydrolase I Feedback Inhibitory Protein Level and Promoting Inducible NO Synthase Dimerization." J Biol Chem 277(49): 47073-47079.
 
81. Patel KB, Stratford MR, Wardman P, Everett SA. Oxidation of tetrahydrobiopterin by biological radicals and scavenging of the trihydrobiopterin radical by ascorbate. Free Radic Biol Med 2002;32(3):203-211.
 
82. Reduction of ortho Mn(III) N-alkylpyridylporphyrins with tetrahydrobiopterin Spasojevic I, Fridovich I FREE RADICAL BIOLOGY AND MEDICINE 33: 25 Suppl. 2 2002
 
83. Rider LG. Schiffenbauer AS. Zito M. Lim KL. Ahmed A. Zemel LS. Rennebohm RM. Passo MH. Summers RM. Hicks JE. Lachenbruch PA. Heyes MP. Miller FW. Neopterin and quinolinic acid are surrogate measures of disease activity in the juvenile idiopathic inflammatory myopathies. Clinical Chemistry. 48(10):1681-1688, 2002
 
84. Rokos H, Beazley WD, Schallreuter KU. Oxidative stress in vitiligo: photo-oxidation of pterins produces H2O2 and pterin-6-carboxylic acid. Biochem Biophys Res Commun 2002;292(4):805-11.
 
85. Rosen GM. Tsai P. Weaver J. Porasuphatana S. Roman LJ. Starkov AA. Fiskum G. Pou S. The role of tetrahydrobiopterin in the regulation of neuronal nitric-oxide synthase-generated superoxide. Journal of Biological Chemistry. 277(43):40275-40280, 2002
 
86. Ruokonen E, Ilkka L, Niskanen M, Takala J. Procalcitonin and neopterin as indicators of infection in critically ill patients. Acta Anaesthesiol Scand 2002;46(4):398-404.
 
87. Sawada H, Nakagoshi M, Reinhardt RK, Ziegler I, Koch PB. Hormonal control of GTP cyclohydrolase I gene expression and enzyme activity during color pattern development in wings of Precis coenia. Insect Biochem Mol Biol 2002;32(6):609-15.
 
88. Schennach H, Murr C, Gachter E, et al., Association between neopterin production and other parameters in a population of blood donor, PTERIDINES 13 (4): 133-139 DEC 2002
 
89. Schennach H. Hessenberger G. Mayersbach P. Schonitzer D. Fuchs D. Acute cytomegalovirus infections in blood donors are indicated by increased serum neopterin concentrations. Medical Microbiology & Immunology. 191(2):115-118, 2002
 
90. Schennach H. Lanthaler AJ. Mayersbach P. Ulmer H. Muell K. Schoenitzer D. Fuchs D. Larcher C. Human parvovirus B19 detection in asymptomatic blood donors: Association with increased neopterin concentrations. Journal of Infectious Diseases. 186(10):1494-1497, 2002
 
91. Schennach H. Murr C. Larcher C. Streif W. Pastner E. Zaknun D. Schonitzer D. Fuchs D. Neopterin concentrations in cord blood: A single-cohort study of paired samples from 541 pregnant women and their newborns. Clinical Chemistry. 48(11):2059-2061, 2002
 
92. Schramek N, Bracher A, Fischer M, Auerbach G, Nar H, Huber R, Bacher A. Reaction mechanism of GTP cyclohydrolase I: single turnover experiments using a kinetically competent reaction intermediate. J Mol Biol 2002;316(3):829-37.
 
93. Setoguchi S, Hirooka Y, Eshima K, Shimokawa H, Takeshita A. Tetrahydrobiopterin improves impaired endothelium-dependent forearm vasodilation in patients with heart failure. J Cardiovasc Pharmacol 2002;39(3):363-8.
 
94. Shintaku, H. (2002). "Disorders of tetrahydrobiopterin metabolism and their treatment." Curr Drug Metab 3(2): 123-31.
 
95. Shiraishi H, Ohtsuki M, Sumi-Ichinose C, Nomura T. Regulations and pathophysiological significance of the biosynthesis of tetrahydrobiopterin in human endothelial cells. Nippon Yakurigaku Zasshi. 2002;120:73P-75P
 
96. Slama-Schwok A, Negrerie M, Berka V, Lambry JC, Tsai AL, Vos MH, Martin JL. Nitric Oxide (NO) Traffic in Endothelial NO Synthase. Evidence for a new NO binding site dependent on tetrahydrobiopterin? J Biol Chem 2002;277(9):7581-6.
 
97. Steinfeld R, Kohlschütter A, Zschocke J, Lindner M, Ullrich K, Lukacs Z. Tetrahydrobiopterin monotherapy for phenylketonuria patients with common mild mutations. Eur J Pediatr 2002;DOI 10.1007/s00431-002-0966-0.
 
98. Stickings P. Cunningham JM. Interleukin-1 beta-induced nitric oxide production and inhibition of insulin secretion in rat islets of Langerhans is dependent upon the nitric oxide synthase cofactor tetrahydrobiopterin. Cytokine. 18(2):81-85, 2002 Apr 21.
 
99. Suzuki T, Inagaki H, Yamakuni T, Nagatsu T, Ichinose H (2002) Enhanced expression of GTP cyclohydrolase I in V-1-overexpressing PC12D cells. Biochem Biophys Res Commun 293: 962-8
 
100. Tachibana D, Fukumasu H, Shintaku H, Fukumasu Y, Yamamasu S, Ishiko O, Yamano T, Ogita S. Decreased plasma tetrahydrobiopterin in pregnant women is caused by impaired 6-pyruvoyl tetrahydropterin synthase activity. Int J Mol Med 2002;9(1):49-52.
 
101. Tanaka J. Koshimura K. Murakami Y. Kato Y. Possible involvement of tetrahydrobiopterin in the trophic effect of insulin-like growth factor-1 on rat pheochromocytoma-12 (PC12) cells. Neuroscience Letters. 328(2):201-203, 2002 Aug 9
 
102. Tarpey MM. Sepiapterin treatment in atherosclerosis. Arteriosclerosis Thrombosis & Vascular Biology. 22(10):1519-1521, 2002
 
103. Toth M, Kukor Z, Valent S. Chemical stabilization of tetrahydrobiopterin by L-ascorbic acid: contribution to placental endothelial nitric oxide synthase activity. Mol Hum Reprod 2002;8(3):271-80.
 
104. Vann LR, Payne SG, Edsall LC, Twitty S, Spiegel S, Milstien S. Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells. J Biol Chem 2002;277(15):12649-56.
 
105. Vasquez-Vivar J, Martasek P, Whitsett J, Joseph J, Kalyanaraman B. The ratio between tetrahydrobiopterin and oxidized tetrahydrobiopterin analogues controls superoxide release from endothelial nitric oxide synthase: an EPR spin trapping study. Biochem J 2002;362(Pt 3):733-9.
 
106. Vasquez-Vivar J. Duquaine D. Whitsett J. Kalyanaraman B. Rajagopalan S. Altered tetrahydrobiopterin metabolism in atherosclerosis - Implications for use of oxidized tetrahydrobiopterin analogues and thiol antioxidants. Arteriosclerosis Thrombosis & Vascular Biology. 22(10):1655-1661, 2002
 
107. Verma S, Maitland A, Weisel RD, et al. Novel cardioprotective effects of tetrahydrobiopterin after anoxia and reoxygenation: Identifying cellular targets for pharmacologic manipulation. J Thorac Cardiovasc Surg 2002;123(6):1074-83.
 
108. Weglage, J., M. Grenzebach, A. v.Teeffelen-Heithoff, T. Marquardt, R. Feldmann, J. Denecke, D. Gödde and H. G. Koch (2002). Tetrahydrobiopterin responsiveness in a large series of phenylketonuria patients. J Inherit Metab Dis 25: 321-322.
 
109. Wei C, Wang Z, Meade A, McDonald J, Stuehr D. (2002) Why do nitric oxide synthases use tetrahydrobiopterin? J Inorg Biochem. 91: 618.
 
110. Werner ER, Bahrami S, Heller R, Werner-Felmayer G. Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein. J Biol Chem 2002;277(12):10129-33.
 
111. Widner B, Leblhuber F, Fuchs D. Increased neopterin and tryptophan degradation in andvanced Parkinson's disease. J Neural Transm 2002;109:181-189.
 
112. Widner B. Laich A. Sperner-Unterweger B. Ledochowski M. Fuchs D. Neopterin production, tryptophan degradation, and mental depression - What is the link?. Brain, Behavior, & Immunity. 16(5):590-595, 2002
 
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