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Literature : 2004
Literature 2004
1. Alp, N. J. and K. M. Channon (2004). "Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease." Arterioscler Thromb Vasc Biol 24(3): 413-20.
 
2. Alp, N. J., M. A. McAteer, J. Khoo, R. P. Choudhury and K. M. Channon (2004). "Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase I overexpression reduces endothelial dysfunction and atherosclerosis in ApoE-knockout mice." Arterioscler Thromb Vasc Biol 24(3): 445-50.
 
3. Avanzas P, Arroyo-Espliguero R, Cosin-Sales J, Aldama G, Pizzi C, Quiles J, Kaski JC. Markers of inflammation and multiple complex stenoses (pancoronary plaque vulnerability) in patients with non-ST segment elevation acute coronary syndromes. Heart. 2004 Aug;90(8):847-52
 
4. Avanzas, P., R. Arroyo-Espliguero, J. Cosin-Sales, J. Quiles, E. Zouridakis and J. C. Kaski (2004). "Prognostic value of neopterin levels in treated patients with hypertension and chest pain but without obstructive coronary artery disease." Am J Cardiol 93(5): 627-9.
 
5. Batinic-Haberle, I., I. I. Spasojevic and I. Fridovich (2004). "Tetrahydrobiopterin rapidly reduces the SOD mimic Mn(III) ortho-tetrakis(N-ethylpyridinium-2-yl)porphyrin." Free Radic Biol Med 37(3): 367-374.
 
6. Berka, V., G. Wu, H. C. Yeh, G. Palmer and A. L. Tsai (2004). "Three different oxygen-induced radical species in eNOS oxygenase under regulation by L-arginine and tetradydrobiopterin." J Biol Chem., online ahead pub
 
7. Blackwell, K. A., J. P. Sorenson, D. M. Richardson, L. A. Smith, O. Suda, K. Nath and Z. S. Katusic (2004). "Mechanisms of aging-induced impairment of endothelium-dependent relaxation: role of tetrahydrobiopterin." Am J Physiol Heart Circ Physiol 287(6): H2448-53.
 
8. Blau, N. and C. R. Scriver (2004). "New approach to treat PKU: how far are we?" Mol Genet Metab: 81: 1-2.
 
9. Blau, N. and H. Erlandsen (2004). "The metabolic and molecular bases of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency." Mol Genet Metab: 82:101-111.
 
10. Cabrerizo, F. M., A. H. Thomas, C. Lorente, M. L. Dantola, G. Petroselli, R. Erra balsells and A. L. Cappatelli (2004). "Generation of reactive oxygen species during the photolyis of 6-(hydroxymethyl)pterin in alkaline aqueus solutions." Helv Chim Acta 87: 349-365.
 
11. Cerone, R., M. C. Schiaffino, A. R. Fantasia, M. Perfumo, L. Birk Moller and N. Blau (2004). "Long-term follow-up of a patient with mild tetrahydrobiopterin-responsive phenylketonuria." Mol Genet Metab 81: 137-139.
 
12. Cherian, L., R. Hlatky and C. S. Robertson (2004). "Comparison of tetrahydrobiopterin and L-arginine on cerebral blood flow after controlled cortical impact injury in rats." J Neurotrauma 21(9): 1196-203.
 
13. Choi, H. J., S. Y. Lee, Y. Cho and O. Hwang (2004). "JNK activation by tetrahydrobiopterin: implication for Parkinson's disease." J Neurosci Res 75(5): 715-21.
 
14. Desviat, L. R., B. Pérez, A. Bèlanger-Quintana, M. Castro, C. Aguado, A. Sánchez, M. J. García, M. Martínez-Pardo and M. Ugarte (2004). "Tetrahydrobiopterin responsiveness: results of the BH4 loading test in 31 Spanish PKU patients and correlation with their genotype." Mol Genet Metab 82: 157-162.
 
15. Ding, Q. F., T. Hayashi, A. R. Packiasamy, A. Miyazaki, A. Fukatsu, H. Shiraishi, T. Nomura and A. Iguchi (2004). "The effect of high glucose on NO and O2- through endothelial GTPCH1 and NADPH oxidase." Life Sci 75(26): 3185-94.
 
16. El Fadili, A., C. Kundig, G. Roy and M. Ouellette (2004). "Inactivation of the Leishmania tarentolae pterin transporter (BT1) and reductase (PTR1) genes leads to viable parasites with changes in folate metabolism and hypersensitivity to the antifolate methotrexate." J Biol Chem 279(18): 18575-82.
 
17. Elzaouk, L., S. Laufs, D. Heerklotz, W. Leimbacher, N. Blau, A. Résibois and B. Thöny (2004). "Nuclear localization of tetrahydrobiopterin biosynthetic enzymes." Biochim Biophys Acta 1670: 56-68.
 
18. Erlandsen, H., A. L. Pey, A. Gamez, B. Perez, L. R. Desviat, C. Aguado, R. Koch, S. Surendran, S. Tyring, R. Matalon, C. R. Scriver, M. Ugarte, A. Martinez and R. C. Stevens (2004). "Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations." Proc Natl Acad Sci U S A.
 
19. Fiege, B., D. Ballhausen, L. Kierat, W. Leimbacher, D. Goriouniv, B. Schircks, B. Thöny and N. Blau (2004). "Plasma tetrahydrobiopterin and its pharmacokinetics following oral administration." Mol Genet Metab: 81: 45-51
 
20. Fortepiani, L. A. and J. F. Reckelhoff (2004). "Treatment with tetrahydrobiopterin reduces blood pressure in male SHR by reducing testosterone synthesis." Am J Physiol Regul Integr Comp Physiol.
 
21. Franco Md, M., E. H. Akamine, Z. B. Fortes, E. M. Kawamoto, C. Scavone, L. R. Britto, M. N. Muscara, S. A. Teixeira, R. C. Tostes, M. H. Carvalho and D. Nigro (2004). "Tetrahydrobiopterin Improves Endothelial Dysfunction and Vascular Oxidative Stress in Microvessels of Intrauterine Undernourished Rats." J Physiol.
 
22. Franscini, N., E. B. Bachli, N. Blau, M. S. Leikauf, A. Schaffner and G. Schoedon (2004). "Gene expression profiling of inflamed human endothelial cells and influence of activated protein C." Circulation 110(18): 2903-9.
 
23. Franscini, N., N. Blau, E. B. Bächli, M. Fischler, A. Schaffner and G. Schoedon (2004). "Functional tetrahydrobiopterin biosynthesis in human platlets." Circulation 110: 186-192.
 
24. Fujiwara, K., K. Mori, Y. S. Kaneko, A. Nakashima, A. Nagasaka, M. Itoh and A. Ota (2004). "Tetrahydrobiopterin biosynthesis in white and brown adipose tissues is enhanced following intraperitoneal administration of bacterial lipopolysaccharide." Biochim Biophys Acta 1670(3): 181-98.
 
25. Furukawa, Y. (2004). "Update on dopa-responsive dystonia: locus heterogeneity and biochemical features." Adv Neurol 94: 127-38.
 
26. Garavaglia, G., F. Invernizzi, M. L. Agostoni Carbone, V. Viscardi, F. Saracino, D. Ghezzi, M. Zeviani, G. Zorzi and N. Nardocci (2004). "GTP-cyclohydrolase I gene mutations in patients with autosomal dominant and recessive GTP-CH1 deficiency: Identification and functional characterization of four novel mutations." J Inher Metab Dis 27: 455-463.
 
27. Gibson, C. L., S. La Rosa, K. Ohta, F. Leurquin, A. Lemacon and C. J. Suckling (2004). "The synthesis of 7-deazagunaines as potential inhibitors of guanosine triphosphate cyclohydrolase I." Tetrahedron 60: 943-959.
 
28. Grotzsch, H., H. Schnorf, M. A. Morris, I. Moix, J. Horvath, O. Prilipko and P. R. Burkhard (2004). "Phenotypic heterogeneity of dopa-responsive dystonia in monozygotic twins." Neurology 62(4): 637-9.
 
29. Harding, C. O., M. Neff, K. Wild, K. Jones, L. Elzaouk, B. Thöny and S. Milstien (2004). "The fate of intravenously administered tetrahydrobiopterin and its implications for heterologous gene therapy of phenylketonuria." Mol Genet Metab: 81:52-57
 
30. Hashimoto, R., T. Nagatsu, T. Ohta, M. Mizutani and I. Omura (2004). "Changes in the concentrations of tetrahydrobiopterin, the cofactor of tyrosine hydroxylase, in blood under physical stress and in depression." Ann N Y Acad Sci 1018: 378-86.
 
31. Hasse, S., N. C. Gibbons, H. Rokos, L. K. Marles and K. U. Schallreuter (2004). "Perturbed 6-tetrahydrobiopterin recycling via decreased dihydropteridine reductase in vitiligo: more evidence for H2O2 stress." J Invest Dermatol 122(2): 307-13.
 
32. Hossain, T., I. Rosenberg, J. Selhub, G. Kishore, R. Beachy and K. Schubert (2004). "Enhancement of folates in plants through metabolic engineering." Proc Natl Acad Sci U S A 101(14): 5158-63.
 
33. Huang, A., Y. Zhang, K. Chen, K. Hatakeyama and J. F. Keaney, Jr. (2004). "Cytokine-Stimulated GTP Cyclohydrolase I Expression in Endothelial Cells Requires Coordinated Activation of Nuclear Factor-{kappa}B and Stat1/Stat3." Circ Res.
 
34. Hung, Y. C., P. S. Tsai, C. J. Huang, S. Yang, J. W. Skimming and M. C. Hsieh (2004). "Change in expression of the guanosine triphosphate cyclohydrolase I in LPS-stimulated rats is tissue specific." Acta Anaesthesiol Taiwan 42(1): 23-31.
 
35. Hwu, W. L., M. Y. Lu, K. Y. Hwa, S. W. Fan and Y. M. Lee (2004). "Molecular chaperons affect GTP cyclohydrolase I mutations in Dopa-responsive dystonia." Ann Neurol 55: 875-878.
 
36. Hyland, K., S. Kasim, K. Egami, L. A. Arnold and H. A. Jinnah (2004). "Tetrahydrobiopterin deficiency and dopamine loss in a genetic mouse model of Lesch-Nyhan disease." J Inherit Metab Dis 27(2): 165-178.
 
37. Hynes, S. O., L. A. Smith, D. M. Richardson, I. Kovesdi, T. O'Brien and Z. S. Katusic (2004). "In vivo expression and function of recombinant GTPCH I in the rabbit carotid artery." Am J Physiol Heart Circ Physiol 286(2): H570-4.
 
38. Iwanaga, N., S. Yamamasu, D. Tachibana, J. Nishio, Y. Nakai, H. Shintaku and O. Ishiko (2004). "Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta." Int J Mol Med 13(1): 117-20.
 
39. Jung, J. H., S. W. Choi and S. Han (2004). "Indirect oxidation of 6-tetrahydrobiopterin by tyrosinase." Biochem Biophys Res Commun 314(4): 937-42.
 
40. Kao, C. D., D. M. Niu, J. T. Chen, D. E. Shan, Y. Y. Lin, Z. A. Wu and K. K. Liao (2004). "Subtle brain dysfunction in treated 6-pyruvoyl-tetrahydropterin synthase deficiency: relationship to motor tasks and neurophysiological tests." Brain Dev 26(2): 93-8.
 
41. Katusic, Z. S. and L. V. d'Uscio (2004). "Tetrahydrobiopterin: mediator of endothelial protection." Arterioscler Thromb Vasc Biol 24(3): 397-8.
 
42. Kawashima, S. (2004). "Malfunction of Vascular Control in Lifestyle-Related Diseases: Endothelial Nitric Oxide (NO) Synthase/NO System in Atherosclerosis." J Pharmacol Sci 96(4): 411-9.
 
43. Khoo, J. P., T. Nicoli, N. J. Alp, J. Fullerton, J. Flint and K. M. Channon (2004). "Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse." Mol Genet Metab 82(3): 251-254.
 
44. Kikuchi, A., A. Takeda, K. Fujihara, T. Kimpara, Y. Shiga, H. Tanji, M. Nagai, H. Ichinose, F. Urano, N. Okamura, H. Arai and Y. Itoyama (2004). "Arg(184)His mutant GTP cyclohydrolase I, causing recessive hyperphenylalaninemia, is responsible for dopa-responsive dystonia with parkinsonism: a case report." Mov Disord 19(5): 590-3.
 
45. Kim, S. T., J. W. Chang, H. N. Hong and O. Hwang (2004). "Loss of striatal dopaminergic fibers after intraventricular injection of tetrahydrobiopterin in rat brain." Neurosci Lett 359(1-2): 69-72.
 
46. Kim, W., H. Erlandsen, S. Surendran, R. C. Stevens, A. Gamez, K. Michols-Matalon, S. K. Tyring and R. Matalon (2004). "Trends in enzyme therapy for phenylketonuria." Mol Ther 10(2): 220-4.
 
47. Kolinsky, M. A. and S. S. Gross (2004). "Biochemical analysis of a mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein." J Biol Chem., ahead online publ.
 
48. Koshimura, K., Y. Murakami, J. Tanaka, M. Yamamoto and Y. Kato (2004). "Effect of tetrahydrobiopterin on nitric oxide synthase-containing cells in the rat hippocampus." Neurosci Res 50(2): 161-7.
 
49. Kuhn, D. M., S. A. Sakowski, M. Sadidi and T. J. Geddes (2004). "Nitrotyrosine as a marker for peroxynitrite-induced neurotoxicity: the beginning or the end of the end of dopamine neurons?" J Neurochem 89(3): 529-36.
 
50. Kure, S., K. Dato, K. Fujii, Y. Aoki, Y. Suzuki, S. Kato and Y. matsubara (2004). "Wild-type phenylalanine hydroxylase activity is enhanced by tetrahydrobiopterin supplemantation in vivo: an implication for therapeutic basis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency." Mol Genet Metab 83: 150-156.
 
51. Lee, D. H., S. K. Koo, K. S. Lee, Y. J. Yeon, H. J. Oh, S. W. Kim, S. J. Lee, S. S. Kim, J. E. Lee, I. Jo and S. C. Jung (2004). "The molecular basis of phenylketonuria in Koreans." J Hum Genet 49(11): 617-21.
 
52. Lorente, C., A. L. Capparelli, A. H. Thomas, A. M. Braun and E. Oliveros (2004). "Quenching of the fluorescence of pterin derivatives by anions." Photochem Photobiol Sci 3(2): 167-73.
 
53. Lu, L. L., Y. Su, C. L. Duan, C. L. Zhao, Y. J. Su, J. Wu, H. Y. Zhao, Q. Y. Xu and H. Yang (2004). "Gene therapy o f tyrosine hydroxylase, aromatic L-amino acid decarboxylase, and GTP cyclohydrolase genes in rat model of Parkinson's disease." Zhonghua Yi Xue Za Zhi 84(18): 1528-32.
 
54. Maita, N., K. Hatakeyama, K. Okada and T. Hakoshima (2004). "Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein." J Biol Chem 279(49): 51534-40.
 
55. Matalon, R., R. Koch, K. Michals-Matalon, K. Moseley, S. Surendran, S. Tyring, H. Erlandsen, A. Gamez, R. C. Stevens, A. Romstad, L. B. Moller and F. Guttler (2004). "Biopterin responsive phenylalanine hydroxylase deficiency." Genet Med 6(1): 27-32.
 
56. Mathieu, D., Y. M. Frapart, J. F. Bartoli, J. L. Boucher, P. Battioni and D. Mansuy (2004). "Very general formation of tetrahydropterin cation radicals during reaction of iron porphyrins with tetrahydropterins: model for the corresponding NO-synthase reaction." Chem Commun (Camb)(1): 54-5.
 
57. Matter, H. and P. Kotsonis (2004). "Biology and chemistry of the inhibition of nitric oxide synthases by pteridine-derivatives as therapeutic agents." Med Res Rev 24(5): 662-84.
 
58. McCarty, M. F. (2004). "Coping with endothelial superoxide: potential complementarity of arginine and high-dose folate." Med Hypotheses 63(4): 709-18.
 
59. Mitchell, B. M., A. M. Dorrance and R. C. Webb (2004). "Phenylalanine improves dilation and blood pressure in GTP cyclohydrolase inhibition-induced hypertensive rats." J Cardiovasc Pharmacol 43(6): 758-63.
 
60. Mitchell, B. M., A. M. Dorrance, A. Ergul and R. C. Webb (2004). "Sepiapterin decreases vasorelaxation in nitric oxide synthase inhibition-induced hypertension." J Cardiovasc Pharmacol 43(1): 93-8.
 
61. Mitchell, B. M., A. M. Dorrance, E. A. Mack and R. C. Webb (2004). "Glucocorticoids Decrease GTP Cyclohydrolase and Tetrahydrobiopterin-dependent Vasorelaxation through Glucocorticoid Receptors." J Cardiovasc Pharmacol 43(1): 8-13.
 
62. Miura, H., H. Qiao, T. Kitagami and T. Ohta (2004). "Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin in the mouse hippocampus." Neuropharmacology 46(3): 340-8.
 
63. Miura, H., H. Qiao, T. Kitagami, T. Ohta and N. Ozaki (2004). "Fluvoxamine, a selective serotonin reuptake inhibitor, suppresses tetrahydrobiopterin levels and dopamine as well as serotonin turnover in the mesoprefrontal system of mice." Psychopharmacology (Berl).online ahead publ
 
64. Mochizuki, S., H. Mizukami, T. Ogura, S. Kure, A. Ichinohe, K. Kojima, Y. Matsubara, E. Kobayahi, T. Okada, A. Hoshika, K. Ozawa and A. Kume (2004). "Long-term correction of hyperphenylalaninemia by AAV-mediated gene transfer leads to behavioral recovery in phenylketonuria mice." Gene Ther. Online ahead Pub
 
65. Nystrom, T., A. Nygren and A. Sjoholm (2004). "Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease." Am J Physiol Endocrinol Metab. online ahead publ
 
66. Oettl, K., J. Greilberger, S. Dikalov and G. Reibnegger (2004). "Interference of 7,8-dihydroneopterin with peroxynitrite-mediated reactions." Biochem Biophys Res Commun 321(2): 379-85.
 
67. Okano, Y., Y. Hase, M. Kawajiri, Y. Nishi, K. Inui, N. Sakai, Y. Tanaka, K. Takatori, M. Kajiwara and T. Yamano (2004). "In vivo studies of phenylalanine hydroxylase by phenylalanine breath test: diagnosis of tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency." Pediatr Res 56(5): 714-9.
 
68. Peng, S. S., W. Y. Tseng, Y. H. Chien, W. L. Hwu and H. M. Liu (2004). "Diffusion tensor images in children with early-treated, chronic, malignant phenylketonuric: correlation with intelligence assessment." AJNR Am J Neuroradiol 25(9): 1569-74.
 
69. Perez-Duenas, B., M. A. Vilaseca, A. Mas, N. Lambruschini, R. Artuch, L. Gomez, J. Pineda, A. Gutierrez, M. Mila and J. Campistol (2004). "Tetrahydrobiopterin responsiveness in patients with phenylketonuria." Clin Biochem 37(12): 1083-90.
 
70. Pey, A. L., B. Perez, L. R. Desviat, M. A. Martinez, C. Aguado, H. Erlandsen, A. Gamez, R. C. Stevens, M. Thorolfsson, M. Ugarte and A. Martinez (2004). "Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations." Hum Mutat 24(5): 388-399.
 
71. Pey, A. L., M. Thorolfsson, K. Teigen, M. Ugarte and A. Martinez (2004). "Thermodynamic Characterization of the Binding of Tetrahydropterins to Phenylalanine Hydroxylase." J Am Chem Soc 126(42): 13670-13678.
 
72. Podjarny, E., G. Hasdan, J. Bernheim, G. Rashid, J. Green, Z. Korzets and J. Bernheim (2004). "Effect of chronic tetrahydrobiopterin supplementation on blood pressure and proteinuria in 5/6 nephrectomized rats." Nephrol Dial Transplant 19(9): 2223-7.
 
73. Ponzone, A., M. Spada, S. Ferraris, I. Dianzani and L. De Sanctis (2004). "Dihydropteridine reductase deficiency in man: From biology to treatment." Med Res Rev 24(2): 127-50.
 
74. Rose, R. B., K. E. Pullen, J. H. Bayle, G. R. Crabtree and T. Alber (2004). "Biochemical and Structural Basis for Partially Redundant Enzymatic and Transcriptional Functions of DCoH and DCoH2(,)." Biochemistry 43(23): 7345-55.
 
75. Santamaria-Araujo, J. A., B. Fischer, T. Otte, M. Nimtz, R. R. Mendel, V. Wray and G. Schwarz (2004). "The tetrahydropyranopterin structure of the sulfur-free and metal-free molybdenum cofactor precursor." J Biol Chem 279(16): 15994-9.
 
76. Saunders-Pullman, R., N. Blau, K. Hylan, J. Zschocke, T. Nygaard, D. Raymond, V. Shanker, K. Mohrmann, L. Arnold, S. Tabbal, D. deLeon, B. Ford, M. Brin, S. Chouinard, L. Ozelius, C. Klein and S. B. Bressman (2004). "Phenylalanine loading as a diagnostic test for Dopa-responsive dystonia: Interpreting the utility of the test." Mol Genet Metab 83: 207-212.
 
77. Schallreuter, K. U., S. M. Elwary, N. C. Gibbons, H. Rokos and J. M. Wood (2004). "Activation/deactivation of acetylcholinesterase by H(2)O(2): more evidence for oxidative stress in vitiligo." Biochem Biophys Res Commun 315(2): 502-508.
 
78. Schallreuter, K. U., U. Wazir, S. Kothari, N. C. Gibbons, J. Moore and J. M. Wood (2004). "Human phenylalanine hydroxylase is activated by H(2)O(2): a novel mechanism for increasing the l-tyrosine supply for melanogenesis in melanocytes." Biochem Biophys Res Commun 322(1): 88-92.
 
79. Schallreuter, K. U., U. Wazir, S. Kothari, N. C. Gibbons, J. Moore and J. M. Wood (2004). "Human phenylalanine hydroxylase is activated by H2O2: a novel mechanism for increasing the L-tyrosine supply for melanogenesis in melanocytes." Biochem Biophys Res Commun 322(1): 88-92.
 
80. Schwarz, G., J. A. Santamaria-Araujo, S. Wolf, H. J. Lee, I. M. Adham, H. J. Grone, H. Schwegler, J. O. Sass, T. Otte, P. Hanzelmann, R. R. Mendel, W. Engel and J. Reiss (2004). "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli." Hum Mol Genet.
 
81. Serova, L. I., S. Maharjan, A. Huang, D. Sun, G. Kaley and E. L. Sabban (2004). "Response of tyrosine hydroxylase and GTP cyclohydrolase I gene expression to estrogen in brain catecholaminergic regions varies with mode of administration." Brain Res 1015(1-2): 1-8.
 
82. Shang, T., S. Kotamraju, S. V. Kalivendi, C. J. Hillard and B. Kalyanaraman (2004). "1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric oxide synthase-derived superoxide." J Biol Chem: ONLINE.
 
83. Shang, T., S. Kotamraju, S. V. Kalivendi, C. J. Hillard and B. Kalyanaraman (2004). "1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide." J Biol Chem 279(18): 19099-112.
 
84. Shi, W., C. J. Meininger, T. E. Haynes, K. Hatakeyama and G. Wu (2004). "Regulation of tetrahydrobiopterin synthesis and bioavailability in endothelial cells." Cell Biochem Biophys 41(3): 415-34.
 
85. Shinozaki K, Kashiwagi A, Masada M, Okamura T. Molecular mechanisms of impaired endothelial function associated with insulin resistance. Curr Drug Targets Cardiovasc Haematol Disord 4(1):1-11.2004
 
86. Shinozaki, K., K. Ayajiki, A. Kashiwagi, M. Masada and T. Okamura (2004). "Malfunction of vascular control in lifestyle-related diseases: mechanisms underlying endothelial dysfunction in the insulin-resistant state." J Pharmacol Sci 96(4): 401-5.
 
87. Shintaku, H., S. Kure, T. Ohura, Y. Okano, M. Ohwada, N. Sugiyama, N. Sakura, I. Yoshida, M. Yoshino, Y. Matsubara, K. Suzuki, K. Aoki and T. Kitagawa (2004). "Long-Term Treatment and Diagnosis of Tetrahydrobiopterin-Responsive Hyperphenylalaninemia with a Mutant Phenylalanine Hydroxylase Gene." Pediatr Res., online ahead pub
 
88. Steinberger, D., N. Blau, D. Goriuonov, J. Bitsch, M. Zuker, S. Hummel and U. Muller (2004). "Heterozygous mutation in 5'-untranslated region of sepiapterin reductase gene (SPR) in a patient with dopa-responsive dystonia." Neurogenetics 5(3): 187-90.
 
89. Steinfeld, R., A. Kohlschütter, K. Ullrich and L. Lukacs (2004). "Efficiency of long-term tetrahydrobiopterin monotherapy in phenylketonuria." J Inher Metab Dis 27: 449-453.
 
90. Suzuki, T., H. Kurita and H. Ichinose (2004). "GTP cyclohydrolase I utilizes metal-free GTP as its substrate." Eur J Biochem 271(2): 349-355.
 
91. Sybesma, W., C. Burgess, M. Starrenburg, D. Sinderen Dv and J. Hugenholtz (2004). "Multivitamin production in Lactococcus lactis using metabolic engineering." Metab Eng 6(2): 109-15.
 
92. Tanaka, T., Y. Nakamura, A. Nasuno, T. Mezaki, K. Higuchi, H. Fukunaga, K. Tsuchida, K. Ozaki, T. Hori, T. Matsubara and Y. Aizawa (2004). "Plasma concentrations of monocyte chemoattractant protein 1 (MCP-1) and neopterin in the coronary circulation of patients with coronary artery disease." Circ J 68(2): 114-20.
 
93. Thoeni, G., E. R. Werner and G. Werner-Felmayer (2004). "Tetrahydropteridines suppress gene expression and induce apoptosis of activated RAW264.7 cells via formation of hydrogen peroxide." Free Radic Biol Med 37(3): 375-85.
 
94. Thöny, B. and N. Blau (2004). "More transgenic mouse models for dopamine deficiency." Ann Neurol 55: 297-298.
 
95. Thöny, B., Z. Ding and A. Martinez (2004). "Tetrahydrobiopterin protects phenylalanine hydroxylase activity in vivo: Implications for tetrahydrobiopterin-responsive hyperphenylalaninemia." FEBS Letters 577: 507-511.
 
96. Topal, G., A. Brunet, E. Millanvoye, J. L. Boucher, F. Rendu, M. A. Devynck and M. David-Dufilho (2004). "Homocysteine induces oxidative stress by uncoupling of no synthase activity through reduction of tetrahydrobiopterin." Free Radic Biol Med 36(12): 1532-41.
 
97. Uncini, A., M. V. De Angelis, P. Di Fulvio, M. Ragno, G. Annesi, A. Filla, L. Stuppia and D. Gambi (2004). "Wide expressivity variation and high but no gender-related penetrance in two dopa-responsive dystonia families with a novel GCH-I mutation." Mov Disord 19(10): 1139-45.
 
98. Valent, S. and M. Toth (2004). "Spectrophotometric analysis of the protective effect of ascorbate against spontaneous oxidation of tetrahydrobiopterin in aqueous solution: kinetic characteristics and potentiation by catalase of ascorbate action." Int J Biochem Cell Biol 36(7): 1266-80.
 
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