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| Literature 2008 |
| 1. |
Ye, J., W. J. Qiu, L. S. Han, H. W. Zhang, J. D. Zhou, X. L. Gao, Y. Wang and X. F. Gu (2008). "Diagnosis, treatment and gene mutation analysis of the first case with dihydropteridine reductase deficiency in the mainland of China." Zhonghua Er Ke Za Zhi 46(4): 281-5.[Chinese]
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| 2. |
Chavan, B., W. Beazley, J. M. Wood, H. Rokos, H. Ichinose and K. U. Schallreuter (2008). "H(2)O (2) increases de novo synthesis of (6R)-L: -erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo." J Inherit Metab Dis. Epub ahead of press
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| 3. |
Peterson, T. E., L. V. d'Uscio, S. Cao, X. L. Wang and Z. S. Katusic (2008). "Guanosine Triphosphate Cyclohydrolase I Expression and Enzymatic Activity Are Present in Caveolae of Endothelial Cells." Hypertension. Epub ahead of press
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Ichinose, H., T. Nomura and C. Sumi-Ichinose (2008). "Metabolism of tetrahydrobiopterin: Its relevance in monoaminergic neurons and neurological disorders." Chem Rec 8(6): 378-385.
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Sarkissian, C. N., A. Gamez, L. Wang, M. Charbonneau, P. Fitzpatrick, J. F. Lemontt, B. Zhao, M. Vellard, S. M. Bell, C. Henschell, A. Lambert, L. Tsuruda, R. C. Stevens and C. R. Scriver (2008). "Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria." Proc Natl Acad Sci U S A. Epub ahead of press
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Campbell, C. M., R. R. Edwards, C. Carmona, M. Uhart, G. Wand, A. Carteret, Y. K. Kim, J. Frost and J. N. Campbell (2008). "Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain." Pain. Epub ahead of press
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Glavas, D., D. Bakovic, A. Obad, I. Palada, T. Breskovic, Z. Valic, A. O. Brubakk and Z. Dujic (2008). "Effects of tetrahydrobiopterin on venous bubble grade and acute diving-induced changes in cardiovascular function." Clin Physiol Funct Imaging. Epub ahead of press
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Park, J. W., E. S. Park, E. N. Choi, H. Y. Park and S. C. Jung (2008). "Altered brain gene expression profiles associated with the pathogenesis of phenylketonuria in a mouse model." Clin Chim Acta Epubahead of press
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Hoke, K. R. and B. R. Crane (2008). "The solution electrochemistry of tetrahydrobiopterin revisited." Nitric Oxide Epub ahead of press
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Koch, R. (2008). "Maternal phenylketonuria and tetrahydrobiopterin." Pediatrics 122(6): 1367-8.
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Katusic, Z. S., L. V. d'Uscio and K. A. Nath (2008). "Vascular protection by tetrahydrobiopterin: progress and therapeutic prospects." Trends Pharmacol Sci. Epub ahead of press
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| 12. |
Artunc, F., M. Essig, N. Artunc, C. Plachtzik, M. Reich, G. Boehmer, H. U. Haering, C. M. Erley and T. Risler (2008). "Effects of tetrahydrobiopterin on nitric oxide bioavailability and renal hemodynamics in healthy volunteers." J Nephrol 21: 850-860.
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Sawabe, K., Y. Saeki, A. Ohashi, K. Mamada, K. O. Wakasugi, H. Matsuoka and H. Hasegawa (2008). "Tetrahydrobiopterin in intestinal lumen: Its absorption and secretion in the small intestine and the elimination in the large intestine." J Inherit Metab Dis. Epub ahead of press
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| 14. |
Feillet, F., L. Clarke, C. Meli, M. Lipson, A. A. Morris, P. Harmatz, D. R. Mould, B. Green, A. Dorenbaum, M. Giovannini and E. Foehr (2008). "Pharmacokinetics of Sapropterin in Patients with Phenylketonuria." Clin Pharmacokinet 47(12): 817-825.
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| 15. |
Lazarev, M., J. Lamb, M. M. Barmada Pitt Edu, F. Dai, M. A. Anderson, M. B. Max and D. C. Whitcomb (2008). "Does the pain-protective GTP cyclohydrolase haplotype significantly alter the pattern or severity of pain in humans with chronic pancreatitis?" Mol Pain 4(1): 58.
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Crabtree, M. J., A. L. Tatham, Y. Al-Wakeel, N. Warrick, A. B. Hale, S. Cai, K. M. Channon and N. J. Alp (2008). "Quantitative regulation of intracellular endothelial nitric oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: Insights from cells with tet-regulated GTP cyclohydrolase I expression." J Biol Chem. Epub ahead of press
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| 17. |
Chen, C., K. H. Seo, H. L. Kim, N. Zhuang, Y. S. Park and K. H. Lee (2008). "Crystallization and preliminary characterization of dihydropteridine reductase from Dictyostelium discoideum." Acta Crystallogr Sect F Struct Biol Cryst Commun 64(Pt 11): 1013-5.
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| 18. |
Willoughby, R. E., T. Opladen, T. Maier, W. Rhead, S. Schmiedel, J. Hoyer, C. Drosten, C. E. Rupprecht, K. Hyland and G. F. Hoffmann (2008). "Tetrahydrobiopterin deficiency in human rabies." J Inherit Metab Dis. Epub ahead of press
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| 19. |
Jung, S. C., J. W. Park, H. J. Oh, J. O. Choi, K. I. Seo, E. S. Park and H. Y. Park (2008). "Protective effect of recombinant adeno-associated virus 2/8-mediated gene therapy from the maternal hyperphenylalaninemia in offsprings of a mouse model of phenylketonuria." J Korean Med Sci 23(5): 877-83.
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Trefz, F. K., D. Scheible, H. Gotz and G. Frauendienst-Egger (2008). "Significance of genotype in tetrahydrobiopterin-responsive phenylketonuria." J Inherit Metab Dis. Epub ahead of press
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| 21. |
Phillips, G., B. El Yacoubi, B. Lyons, S. Alvarez, D. Iwata-Reuyl and V. de Crecy-Lagard (2008). "The biosynthesis of the 7-deazaguanosine modified tRNA nucleosides: a new role for GTP cyclohydrolase-I." J Bacteriol. Epub ahead of press
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| 22. |
Lee, P., E. P. Treacy, E. Crombez, M. Wasserstein, L. Waber, J. Wolff, U. Wendel, A. Dorenbaum, J. Bebchuk, H. Christ-Schmidt, M. Seashore, M. Giovannini, B. K. Burton and A. A. Morris (2008). "Safety and efficacy of 22 weeks of treatment with sapropterin dihydrochloride in patients with phenylketonuria." Am J Med Genet A. Epub ahead of press
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| 23. |
Dobrowolski, S. F., A. L. Pey, R. Koch, H. Levy, C. C. Ellingson, E. W. Naylor and A. Martinez (2008). "Biochemical characterization of mutant phenylalanine hydroxylase enzymes and correlation with clinical presentation in hyperphenylalaninaemic patients." J Inherit Metab Dis. Epub ahead of press
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| 24. |
Svoboda, P., S. H. Ko, B. Cho, S. H. Yoo, S. W. Choi, S. K. Ye, H. Kasai and M. H. Chung (2008). "Neopterin, a marker of immune response, and 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress, correlate at high age as determined by automated simultaneous high-performance liquid chromatography analysis of human urine." Anal Biochem. Epub ahead of press
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| 25. |
Siltberg-Liberles, J., I. H. Steen, R. M. Svebak and A. Martinez (2008). "The phylogeny of the aromatic amino acid hydroxylases revisited by characterizing phenylalanine hydroxylase from Dictyostelium discoideum." Gene. Epub ahead of press
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Ionova, I. A., J. Vasquez Vivar, J. Whitsett, A. Herrnreiter, M. M. Medhora, B. C. Cooley and G. M. Pieper (2008). "Deficient BH4 Production via De Novo and Salvage Pathways Regulates NO Responses to Cytokines in Adult Cardiac Myocytes." Am J Physiol Heart Circ Physiol. Epub ahead of press
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Neurauter, G., K. Schrocksnadel, S. Scholl-Burgi, B. Sperner-Unterweger, C. Schubert, M. Ledochowski and D. Fuchs (2008). "Chronic immune stimulation correlates with reduced phenylalanine turnover." Curr Drug Metab 9(7): 622-7.
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| 28. |
Masano, T., S. Kawashima, R. Toh, S. Satomi-Kobayashi, M. Shinohara, T. Takaya, N. Sasaki, M. Takeda, H. Tawa, T. Yamashita, M. Yokoyama and K. Hirata (2008). "Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats." Circ J 72(9): 1512-9.
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| 29. |
Verbeek, M. M., A. M. Blom, R. A. Wevers, A. J. Lagerwerf, J. van de Geer and M. A. Willemsen (2008). "Technical and biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations." Mol Genet Metab. Epub ahead of press
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| 30. |
Souza, C. P., E. R. Valadares, A. L. Trindade, V. L. Rocha, L. R. Oliveira and A. L. Godard (2008). "Mutation in intron 5 of GTP cyclohydrolase 1 gene causes dopa-responsive dystonia (Segawa syndrome) in a Brazilian family." Genet Mol Res 7(3): 687-94.
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Nascimento, C., J. Leandro, I. Tavares de Almeida and P. Leandro (2008). "Modulation of the Activity of Newly Synthesized Human Phenylalanine Hydroxylase Mutant Proteins by Low-Molecular-Weight Compounds." Protein J. Epub ahead of press
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| 32. |
Sato, K., C. Sumi-Ichinose, R. Kaji, K. Ikemoto, T. Nomura, I. Nagatsu, H. Ichinose, M. Ito, W. Sako, S. Nagahiro, A. M. Graybiel and S. Goto (2008). "Differential involvement of striosome and matrix dopamine systems in a transgenic model of dopa-responsive dystonia." Proc Natl Acad Sci U S A. Epub ahead of press
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| 33. |
Hashiguchi, T., Y. Kakihana, S. Isowaki, T. Kuniyoshi, T. Kaminosono, E. Nagata, K. Tobo, M. Tahara, N. Okayama, Y. Arakawa, Y. Kakihara, T. Goromaru, N. Nakanishi, H. Nakazawa and Y. Kanmura (2008). "Systematic evaluation of nitric oxide, tetrahydrobiopterin, and anandamide levels in a porcine model of endotoxemia." J Anesth 22(3): 213-20.
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| 34. |
Sarkissian, C. N., A. Gamez and C. R. Scriver (2008). "What we know that could influence future treatment of phenylketonuria." J Inherit Metab Dis. Epub ahead of press
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| 35. |
Willoughby, R. E., A. Roy-Burman, K. W. Martin, J. C. Christensen, D. F. Westenkirschner, J. D. Fleck, C. Glaser, K. Hyland and C. E. Rupprecht (2008). "Generalised cranial artery spasm in human rabies." Dev Biol (Basel) 131: 367-75.
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| 36. |
Wang, S., J. Xu, P. Song, Y. Wu, J. Zhang, H. C. Choi and M. H. Zou (2008). "Acute Inhibition of Guanosine Triphosphate Cyclohydrolase 1 Uncouples Endothelial Nitric Oxide Synthase and Elevates Blood Pressure." Hypertension. Epub ahead of press
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| 37. |
Antoniades, C., C. Shirodaria, T. Van Assche, C. Cunnington, I. Tegeder, J. Lotsch, T. J. Guzik, P. Leeson, J. Diesch, D. Tousoulis, C. Stefanadis, M. Costigan, C. J. Woolf, N. J. Alp and K. M. Channon (2008). "GCH1 Haplotype Determines Vascular and Plasma Biopterin Availability in Coronary Artery Disease Effects on Vascular Superoxide Production and Endothelial Function." J Am Coll Cardiol 52(2): 158-165.
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| 38. |
Pey, A. L., M. Ying, N. Cremades, A. Velazquez-Campoy, T. Scherer, B. Thony, J. Sancho and A. Martinez (2008). "Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria." J Clin Invest. Epub ahead of press
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| 39. |
Kim, Y. S., Y. B. Choi, J. H. Lee, S. H. Yang, J. H. Cho, C. H. Shin, S. D. Lee, M. K. Paik and K. M. Hong (2008). "Predisposition of genetic disease by modestly decreased expression of GCH1 mutant allele." Exp Mol Med 40(3): 271-5.
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Feillet, F. (2008). "BH4 in the management of phenylketonuria." Arch Pediatr 15(5): 606-607. [French]
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Genestra, M. (2008). "Roles of tetrahydrobiopterin (BH(4)) cofactor in nitric oxide synthase (NOS) catalysis." Cell Signal. Epub ahead of press
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Williams, R. A., C. D. Mamotte and J. R. Burnett (2008). "Phenylketonuria: an inborn error of phenylalanine metabolism." Clin Biochem Rev 29(1): 31-41.
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| 43. |
Wang, L., A. Gamez, H. Archer, E. E. Abola, C. N. Sarkissian, P. Fitzpatrick, D. Wendt, Y. Zhang, M. Vellard, J. Bliesath, S. M. Bell, J. F. Lemontt, C. R. Scriver and R. C. Stevens (2008). "Structural and Biochemical Characterization of the Therapeutic Anabaena variabilis Phenylalanine Ammonia Lyase." J Mol Biol. Epub ahead of press
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| 44. |
Gersting, S. W., K. F. Kemter, M. Staudigl, D. D. Messing, M. K. Danecka, F. B. Lagler, C. P. Sommerhoff, A. A. Roscher and A. C. Muntau (2008). "Loss of Function in Phenylketonuria is Caused by Impaired Molecular Motions and Conformational Instability." Am J Hum Genet. Epub ahead of press
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| 45. |
Wenzel, P., E. Schulz, M. Oelze, J. Muller, S. Schuhmacher, M. S. Alhamdani, J. Debrezion, M. Hortmann, K. Reifenberg, I. Fleming, T. Munzel and A. Daiber (2008). "AT(1)-receptor blockade by telmisartan upregulates GTP-cyclohydrolase I and protects eNOS in diabetic rats." Free Radic Biol Med. Epub ahead of press
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Supangat, S., S. O. Park, K. H. Seo, S. Y. Lee, Y. S. Park and K. H. Lee (2008). "Role of Phe-99 and Trp-196 of sepiapterin reductase from Chlorobium tepidum in the production of L-threo-tetrahydrobiopterin." Acta Biochim Biophys Sin (Shanghai) 40(6): 513-8
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| 47. |
Matei, V., A. Rodriguez-Vilarrupla, R. Deulofeu, H. Garcia-Caldero, M. Fernandez, J. Bosch and J. C. Garcia-Pagan (2008). "Three-day tetrahydrobiopterin therapy increases in vivo hepatic NOS activity and reduces portal pressure in CCl(4) cirrhotic rats." J Hepatol. Epub ahead of press
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d'Uscio, L. V. and Z. S. Katusic (2008). "Erythropoietin Increases Endothelial Biosynthesis of Tetrahydrobiopterin by Activation of Protein Kinase B{alpha}/Akt1." Hypertension. Epub ahead of press
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Doehring, A., C. Antoniades, K. M. Channon, I. Tegeder and J. Lotsch (2008). "Clinical genetics of functionally mild non-coding GTP cyclohydrolase 1 (GCH1) polymorphisms modulating pain and cardiovascular risk." Mutat Res. Epub ahead of press
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Sawabe, K., K. Yamamoto, Y. Harada, A. Ohashi, Y. Sugawara, H. Matsuoka and H. Hasegawa (2008). "Cellular uptake of sepiapterin and push-pull accumulation of tetrahydrobiopterin." Mol Genet Metab. Epub ahead of press
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Harding, C. O. (2008). "Progress toward cell-directed therapy for phenylketonuria." Clin Genet. Epub ahead of press
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| 53. |
Pascucci, T., D. Andolina, R. Ventura, S. Puglisi-Allegra and S. Cabib (2008). "Reduced availability of brain amines during critical phases of postnatal development in a genetic mouse model of cognitive delay." Brain Res. Epub ahead of press
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| 54. |
Verbeek, M. M., M. A. Willemsen, R. A. Wevers, A. J. Lagerwerf, N. G. Abeling, N. Blau, B. Thony, E. Vargiami and D. I. Zafeiriou (2008). "Two Greek siblings with sepiapterin reductase deficiency." Mol Genet Metab. 94:403-409
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| 55. |
Qu, Y. J., F. Song, Y. W. Jin and H. Wang (2008). "Mutation analysis and one novel mutation detection of 6-pyruvoyl tetrahydropterin synthase gene in children with tetrahydrobiopterin deficiency." Zhongguo Yi Xue Ke Xue Yuan Xue Bao 30(2): 170-4 [Chinese].
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| 56. |
Shahbaz Mohammadi, H., E. Omidinia and H. Taherkhani (2008). "Rapid one-step separation and purification of recombinant phenylalanine dehydrogenase in aqueous two-phase systems." Iran Biomed J 12(2): 115-22.
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| 57. |
Bik-Multanowski, M., J. J. Pietrzyk, B. Didycz and A. Szymczakiewicz-Multanowska (2008). "Development of a model for assessment of phenylalanine hydroxylase activity in newborns with phenylketonuria receiving tetrahydrobiopterin: A potential for practical implementation." Mol Genet Metab. Epub ahead of press (letter)
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| 58. |
Moens, A. L., E. Takimoto, C. G. Tocchetti, K. Chakir, D. Bedja, G. Cormaci, E. A. Ketner, M. Majmudar, K. Gabrielson, M. K. Halushka, J. B. Mitchell, S. Biswal, K. M. Channon, M. S. Wolin, N. J. Alp, N. Paolocci, H. C. Champion and D. A. Kass (2008). "Reversal of Cardiac Hypertrophy and Fibrosis From Pressure Overload by Tetrahydrobiopterin. Efficacy of Recoupling Nitric Oxide Synthase as a Therapeutic Strategy." Circulation. Epub ahead of press
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| 59. |
Calvo, A. C., A. L. Pey, M. Ying, C. M. Loer and A. Martinez (2008). "Anabolic function of phenylalanine hydroxylase in Caenorhabditis elegans." FASEB J. Epub ahead of press
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Hamadate, N., K. Noguchi, M. Sakanashi, T. Matsuzaki and J. Nakasone (2008). "Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats." J Pharmacol Sci. Epub ahead op press
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Haavik, J., N. Blau and B. Thony (2008). "Mutations in human monoamine-related neurotransmitter pathway genes." Hum Mutat 29: 891-902.
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Editors (2008). "Sapropterin treatment for phenylketonuria." Arch Dis Child 93(5): 372.
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Concolino, D., G. Muzzi, M. Rapsomaniki, M. T. Moricca, M. G. Pascale and P. Strisciuglio (2008). "Serum prolactin as a tool for the follow-up of treated DHPR-deficient patients." J Inherit Metab Dis. Epub ahead of press
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| 64. |
Ikemoto, K., T. Matsumoto, M. Ohtsuki, M. Itoh, S. Tada, Y. Udagawa, C. Sumi-Ichinose, K. Kondo and T. Nomura (2008). "2,4-Diamino-6-hydroxypyrimidine (DAHP) suppresses cytokine-induced VCAM-1 expression on the cell surface of human umbilical vein endothelial cells in a BH(4)-independent manner." Biochim Biophys Acta. Epub ahead of press
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| 65. |
Thony, B., A. C. Calvo, T. Scherer, R. M. Svebak, J. Haavik, N. Blau and A. Martinez (2008). "Tetrahydrobiopterin shows chaperone activity for tyrosine hydroxylase." J Neurochem. 106: 672-681
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| 66. |
Horvath, G. A., S. G. Stockler-Ipsiroglu, R. Salvarinova-Zivkovic, Y. P. Lillquist, M. Connolly, K. Hyland, N. Blau, T. Rupar and P. J. Waters (2008). "Autosomal recessive GTP cyclohydrolase I deficiency without hyperphenylalaninemia: Evidence of a phenotypic continuum between dominant and recessive forms." Mol Genet Metab. 91: 127-131
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Wunderlich, C., K. Schober, A. Schmeisser, C. Heerwagen, A. K. Tausche, N. Steinbronn, A. Brandt, M. Kasper, C. Schwencke, R. C. Braun-Dullaeus and R. H. Strasser (2008). "The adverse cardiopulmonary phenotype of caveolin-1 deficient mice is mediated by a dysfunctional endothelium." J Mol Cell Cardiol. Epub ahead od press
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Yum, M. S., T. S. Ko, H. W. Yoo and S. J. Chung (2008). "Autosomal-dominant guanosine triphosphate cyclohydrolase I deficiency with novel mutations." Pediatr Neurol 38(5): 367-9.
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Seujange, Y., S. Eiam-Ong and T. Tirawatnapong (2008). "Role of Angiotensin II on Dihydrofolate Reductase, GTP-Cyclohydrolase 1 and Nitric Oxide Synthase Expressions in Renal Ischemia-Reperfusion." Am J Nephrol 28(4): 692-700.
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| 70. |
Sasaki, N., T. Yamashita, T. Takaya, M. Shinohara, R. Shiraki, M. Takeda, N. Emoto, A. Fukatsu, T. Hayashi, K. Ikemoto, T. Nomura, M. Yokoyama, K. I. Hirata and S. Kawashima (2008). "Augmentation of Vascular Remodeling by Uncoupled Endothelial Nitric Oxide Synthase in a Mouse Model of Diabetes Mellitus." Arterioscler Thromb Vasc Biol. Epub ahead of press
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Pierce, G. L. and T. J. Larocca (2008). "Reduced vascular tetrahydrobiopterin (BH4) and endothelial function with ageing: is it time for a chronic BH4 supplementation trial in middle-aged and older adults?" J Physiol. Epub ahead of press
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Wider, C., L. Skipper, A. Solida, L. Brown, M. Farrer, D. Dickson, Z. K. Wszolek and F. J. Vingerhoets (2008). "Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family." Parkinsonism Relat Disord. Epub ahead of press
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Perez-Reinado, E., M. D. Roldan, F. Castillo and C. Moreno-Vivian (2008). "The NprA nitroreductase required for 2,4-dinitrophenol reduction in Rhodobacter capsulatus is a dihydropteridine reductase." Environ Microbiol. Epub ahead of press
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Cheyette, B. N., S. N. Cheyette, K. Cusmano-Ozog and G. M. Enns (2008). "Dopa-responsive dystonia presenting as delayed and awkward gait." Pediatr Neurol 38(4): 273-5.
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Ding, Z., C. O. Harding, A. Rebuffat, L. Elzaouk, J. A. Wolff and B. Thony (2008). "Correction of murine PKU following AAV-mediated intramuscular expression of a complete phenylalanine hydroxylating system." Mol Ther 16(4): 673-81.
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Ozkor, M. A. and A. A. Quyyumi (2008). "Tetrahydrobiopterin." Curr Hypertens Rep 10(1): 58-64.
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Suzuki, K., K. Uchida, N. Nakanishi and Y. Hattori (2008). "Cilostazol Activates AMP-activated Protein Kinase and Restores Endothelial Function in Diabetes." Am J Hypertens 21(4): 451-7.
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Oertel, B. and J. Lotsch (2008). "Genetic mutations that prevent pain: implications for future pain medication." Pharmacogenomics 9(2): 179-94.
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Nandi, M., P. Kelly, P. Vallance and J. Leiper (2008). "Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production." Vasc Med 13(1): 29-36.
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Daniele, A., G. Cardillo, C. Pennino, M. T. Carbone, D. Scognamiglio, L. Esposito, A. Correra, G. Castaldo, A. Zagari and F. Salvatore (2008). "Five human phenylalanine hydroxylase proteins identified in mild hyperphenylalaninemia patients are disease-causing variants." Biochim Biophys Acta. Epub ahead of press
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Cosentino, F., D. Hurlimann, C. Delli Gatti, R. Chenevard, N. Blau, N. J. Alp, K. M. Channon, M. Eto, P. Lerch, F. Enseleit, F. Ruschitzka, M. Volpe, T. F. Luscher and G. Noll (2008). "Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia." Heart 94(4): 487-92.
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Liu, K. M., T. T. Liu, N. C. Lee, L. Y. Cheng, K. J. Hsiao and D. M. Niu (2008). "Long-term Follow-up of Taiwanese Chinese Patients Treated Early for 6-Pyruvoyl-Tetrahydropterin Synthase Deficiency." Arch Neurol 65(3): 387-92.
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Blau, N. (2008). "Defining tetrahydrobiopterin (BH(4))-responsiveness in PKU." J Inherit Metab Dis 31(1): 2-3.
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Heffernan, K. S., V. J. Vieira and R. J. Valentine (2008). "Microvascular function and ageing: L-arginine, tetrahydrobiopterin and the search for the fountain of vascular youth." J Physiol.Epub ahead of press
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Porkert, M., S. Sher, U. Reddy, F. Cheema, C. Niessner, P. Kolm, D. P. Jones, C. Hooper, W. R. Taylor, D. Harrison and A. A. Quyyumi (2008). "Tetrahydrobiopterin: a novel antihypertensive therapy." J Hum Hypertens. Epub ahead of press
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Feillet, F., C. Chery, F. Namour, A. Kimmoun, E. Favre, E. Lorentz, S. F. Battaglia-Hsu and J. L. Gueant (2008). "Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia." Early Hum Dev. Epub ahead of press
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